New Microbiota-endocrine Axis in Fructose Malabsorption-caused Visceral Hypersensitivity in Irritable Bowel Syndrome.

Who can take part

• For all groups:
• Patients with IBS defined by current Rome criteria (currently IV)
• Adult, aged 18 to 75
• Regulatory criteria :; Membership of a social security scheme; Adult having read and understood the information letter and signed the consent form; Woman of childbearing age with effective contraception for the duration of the study such as oestroprogestins, intrauterine device, tubal ligation, vasectomised partner or sexual abstinence (no heterosexual intercourse for 1 month and a negative urine pregnancy test at inclusion); Postmenopausal women: confirmatory diagnosis (non-medically induced amenorrhoea for at least 12 months prior to the inclusion visit or biologically documented); Women of childbearing age who have been rendered surgically infertile (e.g. hysterectomy, bilateral salpingectomy, bilateral oophorectomy); For the IBS group with fructose malabsorption and visceral hypersensitivity (named group of interest, MalF-HyperSens) (1):
• 25g fructose breath test in favour of fructose malabsorption
• Rectal barostat finding visceral hypersensitivity; For the IBS group with fructose malabsorption and without visceral hypersensitivity (known as the MalF-NormoSens group) (2):
• Fructose breath test at 25g dose in favour of fructose malabsorption
• Rectal barostat finding no visceral hypersensitivity; For the IBS group without fructose malabsorption and visceral hypersensitivity (named NormoF-HyperSens group) (3):
• Fructose breath test at 25g dose in favour of no fructose malabsorption
• Rectal barostat finding visceral hypersensitivity; For the IBS group without fructose malabsorption or visceral hypersensitivity (called the NormoF-NormoSens group) (4):
• Fructose breath test at a dose of 25g in favour of the absence of fructose malabsorption
• Rectal barostat finding no visceral hypersensitivity

Who cannot take part

• Systemic antibiotic use (oral, IV or IM) in the month prior to inclusion
• Patient with organic digestive pathology (chronic inflammatory bowel disease, microscopic colitis, digestive cancer, celiac disease)
• Regulatory criteria :; Pregnant or parturient or breast-feeding woman or proven absence of contraception,; Person deprived of liberty by an administrative or judicial decision or person placed under court protection / sub- guardianship or curatorship,; Person undergoing research participating in another trial / having participated in another trial within a period of 2 weeks,; History of illness or psychological or sensory abnormality likely to prevent the subject from fully understanding the conditions required for participation in the protocol or preventing him/her from giving informed consent
• Patient who has not undergone a fructose breath test or a barostat in our department in the last 10 years