FAPI PET scans to find biliary tract cancers in adults
Tests a new PET scan for finding gallbladder and bile duct cancers.
Plain-language title generated from the registry record
Registry title: Prospective Evaluation of 68Ga-FAPI PET in Biliary Cancers
Key facts
- Where
- Mumbai, IndiaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 90 years old?
Source: NCT07337850, who can take part
Where in India
- Dr.Shraddha PatkarMumbai, IndiaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Tata Memorial Centre
- Trial code
- NCT07337850
- Record updated
- 13 January 2026
- Original description
The goal of this prospective observational study is to evaluate whether Gallium-68 Fibroblast Activation Protein Inhibitor (FAPI) PET/CT can improve detection, staging, and recurrence assessment in adult patients (≥18 years) with suspected or confirmed biliary tract cancers, including gallbladder cancer, cholangiocarcinoma, and post-treatment suspected recurrence.Read full original descriptionShow less
FAP 2: Utility of Gallium-68-Fibroblast Activation Protein Inhibitor (FAPI) PET in Biliary Tract Cancers: A Prospective Study
The goal of this prospective observational study is to evaluate whether Gallium-68 Fibroblast Activation Protein Inhibitor (FAPI) PET/CT can improve detection, staging, and recurrence assessment in adult patients (≥18 years) with suspected or confirmed biliary tract cancers, including gallbladder cancer, cholangiocarcinoma, and post-treatment suspected recurrence.
The main question(s) this study aims to answer are:
Can FAPI PET/CT provide greater sensitivity, specificity and diagnostic accuracy for primary tumors, nodal disease, and metastatic lesions compared to standard FDG PET/CT?
Does FAPI PET/CT offer additional diagnostic yield that may affect clinical decision-making and staging, potentially reducing need for invasive staging procedures?
Researchers will compare FAPI PET/CT with FDG PET/CT to see if FAPI improves detection of metastatic or recurrent disease, especially peritoneal or liver metastasis and lymph node involvement.
Participants will:
Provide written informed consent.
Undergo FAPI PET/CT imaging (baseline and/or at suspected biochemical or radiologic recurrence).
Have quantitative imaging parameters evaluated (SUVmax, tumor-to-liver ratios, metabolic volume).
May undergo comparison with FDG PET/CT and/or follow-up imaging or histopathology as gold standard.
Inclusion: Suspected biliary tract cancers- iHCC and GBC; Male and females ≥ 18 years; Upfront advanced (suspected T3 ,T4, N1, vascular involvement); iGBC (residual, N1); Suspected post-treatment recurrence (biochemical or radiological).
Exclusion: Concurrent Malignancy; Informed consent withdrawal.