Testing NNC0487-0111 for weight loss in adults with obesity
Tests a once-weekly injection against a placebo in adults with obesity.
Plain-language title generated from the registry record
Registry title: AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight
Key facts
- Where
- Anderlecht, Edegem, Gent, Leuven, Mechelen, and Roeselare, BelgiumSee the 6 sites
- Phase
- Phase 3
Where in Belgium
- Hopital ErasmeAnderlecht, BelgiumNo longer taking part
- Universitair Ziekenhuis AntwerpenEdegem, BelgiumNo longer taking part
- Universitair Ziekenhuis GentGent, BelgiumNo longer taking part
- UZ LeuvenLeuven, BelgiumNo longer taking part
- MeclinasMechelen, BelgiumNo longer taking part
- Algemeen Ziekenhuis DeltaRoeselare, BelgiumNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Novo Nordisk A/S
- Trial code
- NCT07339423EU 2024-520440-42-00
- Record updated
- 24 September 2026
- Original description
The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.Read full original descriptionShow less
Efficacy and Safety of NNC0487-0111 s.c. Once-weekly in Participants With Obesity (AMAZE 1)
The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.
Inclusion: Male or female (sex at birth); Informed consent obtained before any study-related activities. Study-related activities are any procedures that are carried out as part of the study, including activities to determine suitability for the study; History of at least one self-reported unsuccessful dietary effort to lose body weight.
Exclusion: Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues before screening; History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records; HbA1c ≥ 6.5% (48 millimole per mole [mmol/mol]) as measured by the central laboratory at screening.