Muscle Changes After Long-Term Hybrid Exercise Training in People With Overweight or Obesity
Tests hybrid exercise training and its effects on muscle in adults with overweight or obesity.
Plain-language title generated from the registry record
Registry title: Long-term Adaptations of Skeletal Muscle After Hybrid Training
Key facts
- Where
- Trikala, GreeceSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 30 and 50 years old?
Source: NCT07341711, who can take part
Where in Greece
- Department of Physical Education and Sport Science Trikala, University of ThessalyTrikala, GreeceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Thessaly
- Trial code
- NCT07341711
- Record updated
- 12 June 2026
- Original description
Obesity is a major challenge for public health and renders it imperative to reduce its prevalence. High intensity interval training (HIIT) is a form of exercise training that can efficiently induce weight loss in adults with overweight or obesity, even in the absence of dietary intake manipulation. Hybrid type training represents a form of HIIT, that incorporates both cardiorespiratory and musculoskeletal stimuli, by combining multiple types of exercise into a circuit-type, interval style workout. Recent evidence suggests that long-term participation in hybrid HIIT results in significant health-related benefits. However, the molecular mechanisms driving the chronic effects of hybrid HIIT on cardiometabolic and musculoskeletal health remains to be elucidated.Read full original descriptionShow less
Long-term Adaptations of Skeletal Muscle in Overweight and Obese Individuals After Hybrid Training
Obesity is a major challenge for public health and renders it imperative to reduce its prevalence. High intensity interval training (HIIT) is a form of exercise training that can efficiently induce weight loss in adults with overweight or obesity, even in the absence of dietary intake manipulation. Hybrid type training represents a form of HIIT, that incorporates both cardiorespiratory and musculoskeletal stimuli, by combining multiple types of exercise into a circuit-type, interval style workout. Recent evidence suggests that long-term participation in hybrid HIIT results in significant health-related benefits. However, the molecular mechanisms driving the chronic effects of hybrid HIIT on cardiometabolic and musculoskeletal health remains to be elucidated.
Inclusion: BMI: >25 kg/m2 and <40 kg/m2; Untrained individuals (abstain >1 year from exercise training); No dietary intervention over the last 6 months preceding the study; Low cardiorespiratory fitness level (VO2max: <45 ml/kg/min); No use of any medication, dietary supplements; Low risk for cardiovascular disease; A weight loss <10% over the last 6 months preceding the study; Free of non-communicable diseases (excluding metabolic syndrome).
Exclusion: Cosumption of anti-inflammatory of pain relief medication; Low participation rate (<80% completion of the exercise training sessions); Unbalanced diet; Participation in additional exercise training regimes.