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Mediterranean diet with a synbiotic supplement in women with polycystic ovary syndrome and obesity

Tests a synbiotic supplement alongside a Mediterranean diet in women with polycystic ovary syndrome.

Plain-language title generated from the registry record
Registry title: The Effects of the Mediterranean Diet and Synbiotics in Polycystic Ovary Syndrome

Key facts

Where
Istanbul, TürkiyeSee the site

AI summary: who the study is looking for

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for women aged 18 to 45 who have PCOS and are overweight or obese. It tests a synbiotic supplement with a Mediterranean diet.

Age
18 to 45 years
Sex
Women only
Disease stage
Diagnosed polycystic ovary syndrome (PCOS), before menopause, with a body mass index (BMI) between 25 and 35 kg/m².
Earlier treatment
Cannot have followed a special diet or a low-calorie diet in the last 3 months. Cannot use oral contraceptives.

Main reasons for not taking part

  • Pregnancy or breastfeeding within the past 6 months
  • Kidney, liver or cardiovascular disease, gout, or high uric acid
  • Type 2 diabetes, high blood pressure, diagnosed anemia, or another metabolic condition needing a special diet
  • Use of oral contraceptives
  • Use of medicines that affect fluid balance, such as diuretics and laxatives

Read by machine on 12 November 2026.

Could this be for you?

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 45 years old?

Source: NCT07342946, who can take part

Where in Türkiye

  • Atlas UniversityIstanbul, TürkiyeContact: Aysenur Calik, Msc,Taking people

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Trial details

Who runs it
Atlas University
Trial code
NCT07342946
Record updated
28 October 2026
Original description
This study will look at whether a reduced-calorie Mediterranean-style eating plan, together with a synbiotic supplement, can improve health measures and quality of life in women who have polycystic ovary syndrome (PCOS) and are overweight or have obesity. Participants will be assigned by chance (like flipping a coin) to receive either the synbiotic supplement or a placebo (a look-alike product with no active ingredients). All participants will follow the same reduced-calorie Mediterranean diet for 8 weeks. The study team will measure body composition and weight-related measurements, and will collect blood samples to evaluate selected laboratory markers before and after the 8-week period. Participants will also complete the PCOSQ-50 quality-of-life questionnaire before and after the intervention. The goal is to better understand the possible role of synbiotic supplementation alongside dietary treatment in PCOS.Read full original descriptionShow less

Effects of a Mediterranean Diet and Synbiotic Supplementation on Anthropometric and Biochemical Parameters and Quality of Life in Obese Women With Polycystic Ovary Syndrome

This study will look at whether a reduced-calorie Mediterranean-style eating plan, together with a synbiotic supplement, can improve health measures and quality of life in women who have polycystic ovary syndrome (PCOS) and are overweight or have obesity. Participants will be assigned by chance (like flipping a coin) to receive either the synbiotic supplement or a placebo (a look-alike product with no active ingredients). All participants will follow the same reduced-calorie Mediterranean diet for 8 weeks. The study team will measure body composition and weight-related measurements, and will collect blood samples to evaluate selected laboratory markers before and after the 8-week period. Participants will also complete the PCOSQ-50 quality-of-life questionnaire before and after the intervention. The goal is to better understand the possible role of synbiotic supplementation alongside dietary treatment in PCOS.

Inclusion: Premenopausal women who are overweight or obese, with a body mass index (BMI) between 25 and 35 kg/m²; Aged 18 to 45 years (reproductive age); Diagnosed with polycystic ovary syndrome (PCOS); No underlying metabolic diseases, including type 2 diabetes mellitus, hypertension, diagnosed anemia, or any other metabolic condition requiring a special diet.

Exclusion: Occasional or current use of medications that may affect fluid balance, including diuretics and laxatives; Presence of comorbid conditions, including kidney, liver, or cardiovascular disease, gout, hyperuricemia, or other related disorders; Participants will be withdrawn from the study in case of abnormal biochemical parameters, non-adherence to the prescribed diet, or failure to comply with the supplementation protoco; Pregnancy or breastfeeding within the past 6 months; Use of oral contraceptives; Following a special dietary treatment or a hypocaloric diet within the last 3 months.

ClinicalTrials.gov NCT07342946