Root canal treatment and heart risk markers in people with stable coronary artery disease
Tests whether root canal treatment changes heart risk blood markers in coronary artery disease.
Plain-language title generated from the registry record
Registry title: THE EFFECT OF ENDODONTIC TREATMENT ON CARDIOVASCULAR RISK BIOMARKERS IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE
Key facts
- Where
- Rohtak, IndiaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 30 and older who have stable coronary artery disease and a long-lasting infection at the tip of a tooth root (chronic apical periodontitis).
- Age
- 30 years and older
- Sex
- All sexes can join.
- Disease stage
- Stable coronary artery disease, and chronic apical periodontitis with at least 1 radiographic radiolucency (3mm or more), a periapical index (PAI) score of 3 or more in a single permanent tooth, and pulp necrosis.
- Earlier treatment
- No steroids taken through the body, immunosuppressants, hormone replacement therapy, contraceptives or antibiotics taken through the body in the last 3 months.
Main reasons for not taking part
- Diabetes, rheumatoid arthritis, rheumatic fever, cancer, lung disease or kidney disease
- Gum disease (periodontal disease)
- Acute symptoms
- History of smoking
- Obesity (BMI 30 or more), pregnancy or breastfeeding
Read by machine on 9 November 2026.
Where in India
- Post Graduate institute of Dental Sciences, RohtakRohtak, IndiaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Postgraduate Institute of Dental Sciences Rohtak
- Trial code
- NCT07343804
- Record updated
- 15 January 2026
- Original description
Study subjects were obtained from the pool of OPD patients in the Department of Conservative Dentistry and Endodontics, PGIDS, Rohtak, and the Department of Cardiology, PGIMS, Rohtak. Baseline clinical, radiographic, and laboratory parameters (hsCRP and IL-6) were recorded. Patients were then randomly allocated to one of the two groups. In the test group, single-sitting root canal treatment was performed immediately, while in the control group, delayed endodontic intervention (after 3 months) was performed after three months. Clinical and laboratory parameters were again assessed at the end of 3 months in both groups. hsCRP and IL-6 indices were again done in the delayed treatment group after 3 months of root canal treatment.Read full original descriptionShow less
THE EFFECT OF ENDODONTIC TREATMENT ON CARDIOVASCULAR RISK BIOMARKERS IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE : A RANDOMIZED CONTROLLED TRIAL
Study subjects were obtained from the pool of OPD patients in the Department of Conservative Dentistry and Endodontics, PGIDS, Rohtak, and the Department of Cardiology, PGIMS, Rohtak. Baseline clinical, radiographic, and laboratory parameters (hsCRP and IL-6) were recorded. Patients were then randomly allocated to one of the two groups. In the test group, single-sitting root canal treatment was performed immediately, while in the control group, delayed endodontic intervention (after 3 months) was performed after three months. Clinical and laboratory parameters were again assessed at the end of 3 months in both groups. hsCRP and IL-6 indices were again done in the delayed treatment group after 3 months of root canal treatment.
Inclusion: Individuals 30 years of age and older, with a diagnosis of stable coronary artery disease (CAD) and chronic apical periodontitis; All patients had to present with CAD defined by the Brazilian Society of Cardiology (Xavier et al., 2013) as the documented occurrence of one or more of the following events 6 months before entering the study: history of myocardial infarction, stable angina or ischaemia in non-invasive tests; surgical or percutaneous myocardial revascularization and lesion size of greater than 50% in at least one major coronary artery, as assessed by angiography; presence of angina and positive results of non-invasive testing of ischaemia; Presence of apical periodontitis defined by the presence of at least 1 radiographic radiolucency ( ≥ 3mm) in teeth as assessed both clinically and radiographically ,with periapical index (PAI) scores ≥3 in a single permanent tooth and pulp necrosis verified by cold and electric pulp test; -.
Exclusion: Medications (during last 3 months) known to affect systemic inflammatory markers (systemic steroids,immunosuppressants, hormone replacement therapy, contraceptives and systemic antibiotics; Chronic conditions associated with periodontitis or with changes in systemic inflammation (e.g. diabetes mellitus, rheumatoid arthritis, rheumatic fever, malignancy, respiratory diseases, renal diseases); Presence of localized or diffuse periodontal disease; Presence of CV risk factor - history of smoking; Acute conditions known to affect systemic inflammatory markers (orthopaedic trauma, surgery ,viral infections); Acute symptomatic patients; Obesity (body mass index [BMI]≥30 kg/m2; Pregnancy \& Lactation.37.