How short-term intensive statin treatment changes blood fats after ischemic stroke
Observes how statins change cholesterol in adults after ischemic stroke with narrowed arteries.
Plain-language title generated from the registry record
Registry title: Effects of Short-term Intensive Statin Therapy on Lipid Levels
Key facts
- Where
- Shenyang, ChinaSee the site
Where in China
- Lu WangShenyang, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- General Hospital of Shenyang Military Region
- Trial code
- NCT07344610
- Record updated
- 15 January 2026
- Original description
Acute cerebral infarction (ACI), often linked to arterial stenosis, is a major cause of death and disability. Statins are cornerstone therapies for secondary prevention, effectively lowering LDL-C and stabilizing plaques. However, patient response to intensive statin therapy varies significantly. This prospective study aims to analyze the short-term lipid-lowering effects and influencing factors of such therapy in ACI patients with stenosis, to guide personalized treatment and improve outcomes.Read full original descriptionShow less
Effects of Short-term Intensive Statin Therapy on Lipid Levels in Patients With Ischemic Stroke or Large Artery Atherosclerosis: A Prospective Observational Study
Acute cerebral infarction (ACI), often linked to arterial stenosis, is a major cause of death and disability. Statins are cornerstone therapies for secondary prevention, effectively lowering LDL-C and stabilizing plaques. However, patient response to intensive statin therapy varies significantly. This prospective study aims to analyze the short-term lipid-lowering effects and influencing factors of such therapy in ACI patients with stenosis, to guide personalized treatment and improve outcomes.
Inclusion: Age ≥ 18 years; Diagnosis of ischemic stroke (within 14 days of onset) confirmed by cranial CT/MRI; or imaging-confirmed intracranial/extracranial atherosclerotic stenosis (stenosis rate ≥ 50%); Intensive statin therapy (e.g., atorvastatin 40-80 mg/day or rosuvastatin 20 mg/day) initiated within 24 hours of admission, with a planned continuous application for at least one week; Signed informed consent form.
Exclusion: Use of statin therapy within 1 week prior to admission; Receiving other lipid-lowering treatments; Participation in other drug clinical trials within 3 months; Presence of other serious comorbidities (e.g., malignant tumors, end-stage heart failure) with an expected survival of <1 year; Other conditions deemed unsuitable by the investigator; Pregnant or lactating women.