Magnetic brain stimulation to test bowel symptoms in adults with irritable bowel syndrome
Tests magnetic brain stimulation for gut symptoms in adults with irritable bowel syndrome.
Plain-language title generated from the registry record
Registry title: Study on Treatment Mechanisms and Efficacy Prediction of Individualized Transcranial Magnetic Stimulation in Adults With Irritable Bowel Syndrome Using Multimodal MRI and High-Throughput Sequencing
Key facts
- Where
- Hangzhou, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with irritable bowel syndrome (IBS) who have stopped their IBS medicines. It tests magnetic stimulation of the brain (TMS) with brain scans and stool tests.
- Age
- 18 to 75 years (the summary text says 18-59 years)
- Sex
- All sexes can join.
- Disease stage
- Irritable bowel syndrome (IBS) that meets the Rome IV diagnostic criteria.
- Earlier treatment
- Must have stopped IBS-related medicines for more than 2 weeks. Must not have taken substances such as probiotics or prebiotics in the 3 months before joining.
Main reasons for not taking part
- Cannot have MRI or TMS safety problems, such as metal implants in the body, claustrophobia, epilepsy or skull defects
- Mental illness such as schizophrenia or bipolar disorder that needs ongoing medicine or psychotherapy
- Pregnant, breastfeeding or planning pregnancy during the study
- Severe illness needing hospital care, such as acute infection, heart attack or stroke
- Healthy volunteers cannot join
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT07345377, who can take part
Where in China
- The Affiliated Hospital of Hangzhou Normal UniversityHangzhou, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- The Affiliated Hospital of Hangzhou Normal University
- Trial code
- NCT07345377
- Record updated
- 1 June 2026
- Original description
The goal of this clinical trial is to explore if "individualized repetitive Transcranial Magnetic Stimulation (TMS)" works to improve symptoms in adults with Irritable Bowel Syndrome (IBS). It also aims to learn how this treatment works (by looking at links between the brain, gut, and gut bacteria) and if tests like brain scans or gut bacteria checks can show if the treatment will work for a person. The main questions it aims to answer are:Read full original descriptionShow less
Exploratory Clinical Study to Investigate the Therapeutic Mechanisms, Efficacy Prediction, and Safety Profile of Individualized Transcranial Magnetic Stimulation as a Therapeutic Intervention in Adult Participants Diagnosed With Irritable Bowel Syndrome, Utilizing Multimodal Magnetic Resonance Imaging for Neuroimaging Assessment and High-Throughput Sequencing for Fecal Microbiota Analysis and Metabolic Profile Detection
The goal of this clinical trial is to explore if "individualized repetitive Transcranial Magnetic Stimulation (TMS)" works to improve symptoms in adults with Irritable Bowel Syndrome (IBS). It also aims to learn how this treatment works (by looking at links between the brain, gut, and gut bacteria) and if tests like brain scans or gut bacteria checks can show if the treatment will work for a person. The main questions it aims to answer are:
Will individualized TMS improve IBS symptoms (like stomach pain or discomfort) and affect the links between the brain, gut, and gut bacteria? Can brain scan results (from multimodal Magnetic Resonance Imaging, MRI) and gut bacteria checks (from high-throughput sequencing) predict how well a person responds to TMS?
Participants will be adults aged 18-59 who:
Meet the Rome Ⅳ criteria for IBS (a standard way to diagnose IBS); Have stopped taking IBS-related medicines for more than 2 weeks; Do NOT have MRI or TMS contraindications (like metal implants in the body, mental illness, pregnancy, or serious illnesses requiring hospital stays).
Participants will:
Receive 10 TMS sessions (5 times a week, for 2 weeks total) - TMS is a non-invasive treatment that uses gentle magnetic pulses on the scalp;
Before the first TMS session, and again after the 10th session:
Fill out surveys to rate IBS symptoms; Have an MRI scan (painless, takes about 60 minutes) to look at brain activity; Provide a small stool sample to check gut bacteria.
Inclusion: Meets the Rome IV diagnostic criteria for Irritable Bowel Syndrome (IBS); Has discontinued IBS-related medications for more than 2 weeks prior to enrollment; Aged between 18 and 75 years (inclusive); Has sufficient cognitive ability to provide informed consent, understand study instructions, and complete questionnaires.
Exclusion: Has taken any substances that may affect study indicators (e.g., probiotics, prebiotics) within 3 months prior to enrollment; Has contraindications to MRI (e.g., metal implants in the body, claustrophobia) or TMS (e.g., history of epilepsy, skull defects); Diagnosed with mental illnesses (e.g., schizophrenia, bipolar disorder) that require ongoing medication or psychotherapy; Presents signs of severe illness requiring hospitalization (e.g., hemodynamic instability, acute infection, acute myocardial infarction, cerebral infarction); Women who are pregnant, breastfeeding, or planning to become pregnant during the study period.