Association Between Autonomic Dysfunction and Choroidal Vascularity Index in Fibromyalgia
Key facts
- Who runs it
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
- Where
- Türkiye1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 80 people enrolled
- Started
- 20 Oct 2025
- Ended
- 19 Dec 2025
- Type of study
- Observational, 2 groups
- Record updated
- 8 April 2026
Who can take part
- Age
- 18 years to 50 years
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
Show all 7 criteriaShow less
Who can take part
- Age 18-50 years, female or male
- Fibromyalgia group: diagnosis of fibromyalgia according to 2016 ACR criteria
- Ability and willingness to provide written informed consent
- Adequate ocular media clarity suitable for OCT imaging
- Control group: age- and sex-matched healthy volunteers
Who cannot take part
- Ocular exclusions: cataract or other media opacity; glaucoma or optic nerve disease; ocular surface disorders (e.g., dry eye disease); retinal diseases (e.g., diabetic retinopathy, macular disease); ocular surgery or eye/head trauma within the last 3 months; best-corrected visual acuity < 20/20; refractive error > ±3.00 diopters; intraocular pressure > 21 mmHg; use of topical ophthalmic medications
- Systemic/neurologic exclusions: diabetes mellitus; hypertension; hyperlipidemia; thyroid disorders; inflammatory rheumatic/autoimmune diseases; polyneuropathy or neurodegenerative disease; major depressive disorder or anxiety disorder; heavy smoking (>20 cigarettes/day); alcohol or substance dependence; excessive caffeine intake (>2.5 cups/day)
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
Fibromyalgia is frequently accompanied by autonomic nervous system dysfunction, often characterized by sympathetic predominance. Alterations in ocular microcirculation have been reported in the presence of autonomic dysfunction, including potential reductions in choroidal vascular parameters. This observational study aims to examine the association between autonomic symptom burden and the choroidal vascularity index (CVI), a quantitative marker of choroidal vascular structure derived from optical coherence tomography (OCT), in individuals with fibromyalgia compared with age- and sex-matched healthy controls.
The 2 groups in the trial
- Fibromiyalgia
Adults aged 18-50 years meeting the 2016 ACR criteria for fibromyalgia.
- Healthy Controls
Age- and sex-matched healthy volunteers without fibromyalgia or major systemic/ocular disease.
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Association Between Autonomic Nervous System Dysfunction and Choroidal Vascularity Index (CVI) in Patients With Fibromyalgia: A Cross-Sectional Observational Case-Control Study
- Record updated
- 8 April 2026