Extra stitches versus standard joining of the bowel after surgery for low rectal cancer
Compares extra stitches with the standard bowel join in adults having low rectal cancer surgery.
Plain-language title generated from the registry record
Registry title: Reinforced Versus Conventional Anastomosis in Laparoscopic Low Rectal Cancer Resection: A Comparative Study
Key facts
- Where
- Shanghai, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with cancer in the lower rectum who are planned for keyhole (laparoscopic) surgery to remove part of the rectum.
- Age
- 18 to 85 years
- Sex
- All sexes can join.
- Disease stage
- Adenocarcinoma of the low rectum, within 7 cm (2.8 in) of the anal verge, clinical stage I-III, with no distant spread.
- Earlier treatment
- Cannot have had earlier radiotherapy to the pelvis or major pelvic surgery.
Main reasons for not taking part
- Distant metastases or another cancer at the same time
- Earlier pelvic radiotherapy or major pelvic surgery
- Severe uncontrolled heart, lung, liver or kidney disease
- Emergency surgery, for example bowel obstruction or perforation
- Pregnancy or breastfeeding
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 85 years old?
Source: NCT07346534, who can take part
Where in China
- Shanghai Tenth People's HospitalShanghai, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Shanghai 10th People's Hospital
- Trial code
- NCT07346534
- Record updated
- 22 October 2026
- Original description
Study Description This prospective, controlled clinical study aims to compare the clinical outcomes of reinforced anastomosis using 8-10 interrupted sutures versus the conventional Dixon procedure in patients undergoing laparoscopic low anterior resection for low rectal cancer. Anastomotic leakage remains one of the most significant postoperative complications following low rectal cancer surgery, particularly in laparoscopic procedures due to limited tactile feedback and maneuverability in the pelvic cavity.Read full original descriptionShow less
Reinforced Versus Conventional Anastomosis in Laparoscopic Low Rectal Cancer Resection: A Comparative Study
Study Description This prospective, controlled clinical study aims to compare the clinical outcomes of reinforced anastomosis using 8-10 interrupted sutures versus the conventional Dixon procedure in patients undergoing laparoscopic low anterior resection for low rectal cancer. Anastomotic leakage remains one of the most significant postoperative complications following low rectal cancer surgery, particularly in laparoscopic procedures due to limited tactile feedback and maneuverability in the pelvic cavity.
Reinforcement of the anastomotic site through additional interrupted suturing may provide better mechanical strength and improved healing, potentially reducing the incidence of anastomotic leakage and related morbidities. In this study, eligible patients will be assigned to receive either a conventional laparoscopic Dixon procedure or the same procedure with added reinforcement of the anastomosis using 8-10 interrupted sutures circumferentially.
Perioperative outcomes including the rate of anastomotic leakage, postoperative complications, operation time, length of hospital stay, return of bowel function, and quality of life will be assessed and compared between the two groups. The study seeks to provide evidence for optimizing surgical techniques in low rectal cancer treatment and improving patient prognosis.
Inclusion: Age between 18 and 85 years; Diagnosed with low rectal adenocarcinoma located within 7 cm from the anal verge by colonoscopy and biopsy; Scheduled for elective laparoscopic low anterior resection (Dixon procedure); Clinical stage I-III (based on preoperative imaging, e.g., MRI/CT) without distant metastasis; Adequate organ function (hematologic, hepatic, renal) to tolerate surgery; Provided written informed consent and willing to comply with study procedures and follow-up.
Exclusion: History of prior pelvic radiotherapy or major pelvic surgery; Presence of synchronous distant metastases or other malignancies; Severe uncontrolled comorbidities (e.g., severe cardiovascular, respiratory, hepatic or renal insufficiency); Emergency surgery indication (e.g., bowel obstruction, perforation); Known allergy or contraindication to anesthesia or surgical materials used; Pregnancy or breastfeeding; Participation in another interventional clinical trial within the last 3 months.