TcPRF for Knee Osteoarthritis
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- Who runs it
- National and Kapodistrian University of Athens
- Trial code
- NCT07351981
- Record updated
- 20 January 2026
- Original description
ObjectivesRead full original descriptionShow less
Randomized Double-Blind Study to Evaluate the Efficacy of Transcutaneous Pulsed Radiofrequency (PRF) Treatment for Knee Pain
Objectives
* Primary Objective: To evaluate the efficacy of transcutaneous PRF treatment in reducing knee pain compared to a sham intervention * Secondary Objectives: To assess the improvement in functional outcomes and patient satisfaction following PRF treatment.
Study Design
* Type: Randomized, double-blind, sham-controlled study. * Duration: 6 months * Study Population: Adults aged 40-75 years with chronic knee pain (lasting ≥ 6 months) due to osteoarthritis (OA). * How many patients in each group: 25 patients in each group (according to Janssens et al, 2024) Inclusion Criteria * Diagnosed with knee osteoarthritis according to NICE criteria. * Chronic knee pain (Visual Analogue Scale [VAS] ≥ 4). * Failure to respond adequately to conventional treatments (e.g., NSAIDs, physical therapy). * Willingness to comply with study procedures. Exclusion Criteria * Previous PRF/RF treatment for knee pain. * Hyaluronic acid injection for knee pain in the past 6 months * Knee surgery within the last 6 months. * Severe cardiovascular, neurological, or psychiatric conditions. * Active systemic infections or local skin infections at the knee. * Pregnancy or lactation.
Inclusion: Diagnosed with knee osteoarthritis according to NICE criteria; Chronic knee pain (Visual Analogue Scale [VAS] ≥ 4); Failure to respond adequately to conventional treatments (e.g., NSAIDs, physical therapy); Willingness to comply with study procedures. Exclusion Criteria; Previous PRF/RF treatment for knee pain; Hyaluronic acid injection for knee pain in the past 6 months; Knee surgery within the last 6 months; Severe cardiovascular, neurological, or psychiatric conditions; Active systemic infections or local skin infections at the knee; Pregnancy or lactation.