Heart CT scans for people with a family history of coronary artery disease
Uses heart CT scans to look for risky artery plaque in symptom-free people.
Plain-language title generated from the registry record
Registry title: High-risk Coronary Atherosclerosis in Subjects With Family History of Myocardial Infarction
Key facts
- Where
- Milan, ItalySee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 70 years old?
Source: NCT07352111, who can take part
Where in Italy
- Ospedale Galeazzi-Sant'Ambrogio IRCCSMilan, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
- Trial code
- NCT07352111
- Record updated
- 21 January 2026
- Original description
The evidence of high-risk atherosclerosis at cardiac CT (CCT) may support aggressive primary prevention treatment, reducing the risk of future cardiovascular events. Family history of coronary artery disease (CAD) is a risk factor for cardiovascular events but limited data described the prevalence of coronary atherosclerosis in these patients.Read full original descriptionShow less
High-risk Coronary Atherosclerosis in Subjects With Family History of Myocardial Infarction; the FAMILY Study
The evidence of high-risk atherosclerosis at cardiac CT (CCT) may support aggressive primary prevention treatment, reducing the risk of future cardiovascular events. Family history of coronary artery disease (CAD) is a risk factor for cardiovascular events but limited data described the prevalence of coronary atherosclerosis in these patients.
Aims of the FAMILY project are to explore the prevalence of high-risk coronary atherosclerosis among patients with family history of CAD, to explore whether CCT in this setting may to reclassify patients' vs standard of care and to explore correlations between genetic background and high risk and potentially unstable coronary atherosclerosis.
A consecutive cohort of asymptomatic of patients with family history of CAD will be prospectively enrolled. A per-protocol CCT with advanced atherosclerosis analysis will be performed. At the time of CCT a blood sample will be collected for bio-humoral and genetic investigation. The prevalence of high risk atherosclerosis will be quantified, the reclassification rate of CCT vs clinical evaluation evaluated and the potential in vivo association between genetic profile and high risk atherosclerosis explored.
Inclusion: patients with postive family history of CAD.
Exclusion: known cardiovascular diseases; any symptoms.