Tests cizutamig in adults with moderate to severe ulcerative colitis
Tests cizutamig, a biological medicine, in adults with ulcerative colitis.
Plain-language title generated from the registry record
Registry title: A Study of Cizutamig for Patients With Ulcerative Colitis
Key facts
- Where
- Shanghai, ChinaSee the site
- Phase
- Early phase 1
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT07353450, who can take part
Where in China
- Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Ruijin Hospital
- Trial code
- NCT07353450
- Record updated
- 20 January 2026
- Original description
A Study of Cizutamig for Patients with Ulcerative ColitisRead full original descriptionShow less
An Open-Label, Single Center Study Evaluating the Safety, Tolerability, and Immunogenicity of Cizutamig for Patients With Moderate to Severe Ulcerative Colitis
A Study of Cizutamig for Patients with Ulcerative Colitis
Inclusion: 18-75 years of age at the time of signing the informed consent form (ICF); Have an established diagnosis of UC; Have current evidence of active moderate to severe UC; Have current evidence of UC extending proximal to the rectum; Demonstrated intolerance or inadequate response to ≥ 1 biologic and/or other advanced therapies; Stable use of any of the following background therapy (alone or in combination) up to Day 1; Have documentation of:; A surveillance colonoscopy (performed according to local standards) within 12 months of or during Screening, for patients with pancolitis of > 8 years duration, left-sided colitis of > 12 years duration, or primary sclerosing cholangitis; OR; In patients for whom Inclusion Criteria 7a does not apply, up-to-date colorectal cancer surveillance (performed according to local standard), for patients with family history of colorectal cancer, personal history of increased colorectal cancer risk, age > 50 years, or other known risk factors -.
Exclusion: History of splenectomy, including patients with functional asplenia 20. Any serious medical condition or abnormality on clinical laboratory testing 21. Inability to comply with contraception requirements as specified in the protocol.