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Virtual Reality for ICU Delirium Prevention

Key facts

Who runs it
Cedars-Sinai Medical Center
Where
Los Angeles, United StatesSee the site
Trial code
Status
Recruiting
People taking part
822 people, planned
Started
10 Mar 2026
Expected to end
Apr 2028
Type of study
Interventional, 2 groupsOne group gets no study treatment, for comparison.
Treatments tested
  • Virtual Reality therapeutics
Record updated
17 March 2026

Who can take part

Age
18 years and older
Sex
Women and men
Healthy volunteers
Can take part

The registry criteria, word for word

Show all 17 criteriaShow less

Who can take part

  • Individuals who are currently admitted to the SICU at Cedars-Sinai Medical Center
  • Expected ICU stay >48 hours
  • Richmond Agitation Sedation Scale (RASS) score between -1 to +2
  • CAM-ICU negative
  • 1≤ risk factor for delirium (Age ≥ 65 years old, history of cognitive impairment, sepsis, Sequential Organ Failure Assessment (SOFA) score >5, history of alcohol or benzodiazepine abuse, recent major surgery)

Who cannot take part

  • Self-reported history of severe motion sickness
  • Having had a seizure in the past year
  • Unwilling and/or unable to participate
  • Intubation of tracheostomy
  • Inability to follow commands (e.g. severe aphasia, deafness, GCS<13)
  • The presence of a facial/head deformity that will prohibit the wearing of a VR head mounted device (HMD
  • Those that require corrective lenses -2.5 or stronger that cannot be corrected with contact lenses
  • Unable to understand the instructions or to consent to participation in the study
  • Those who are pregnant
  • Hemodynamic instability (MAP<65 despite support)
  • End-of-life care
  • Severe agitation or delirium (i.e. CAM-ICU + screen)

Where in United States

  • Cedars-Sinai Medical CenterLos Angeles, United StatesTaking people

About the trial

What the trial wants to find out

The purpose of this study is to evaluate whether daily exposure to immersive virtual reality (VR) can reduce the incidence of delirium in high-risk, non-intubated ICU patients. Participants will be randomized to either standard ICU care or standard care plus once-daily 15-minute VR sessions consisting of calming natural scenes, guided meditation, and music. The study population includes adult surgical ICU patients at Cedars-Sinai who are CAM-ICU negative at enrollment and possess at least one established risk factor for delirium. Outcomes will include the incidence and duration of delirium, ICU and hospital length of stay, feasibility of the VR intervention, and the frequency of adverse events. By targeting a high-risk population with an innovative non-pharmacologic therapy, this trial aims to generate data to support integration of VR into ICU delirium prevention protocols.

The 2 groups in the trial

  • Standard ICU delirium preventionNo study treatment, for comparison
  • Study ICU Delirium Prevention and VR treatmentTreatment being tested

    Treatment: Virtual Reality therapeutics

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
VR for ICU Delirium Prevention
Record updated
17 March 2026