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NCT07357766WithdrawnPhase 3

A Research Study to Compare Different Versions of Injectable CagriSema and Placebo in People With Excess Body Weight

Run by Novo Nordisk A/S

A Placebo-controlled Comparability Study to Compare Two Presentations of CagriSema in Participants With Overweight or Obesity

Source: ClinicalTrials.gov · Last updated 9 Jul 2026

Reason given: The study is withdrawn due to strategic reasons.

Brief summary (registry, in English)

This study is being done to find out how well a medicine called CagriSema helps people with overweight or obesity lose weight. CagriSema is still being tested in studies and is not yet available for doctors to prescribe. In this study the sponsor will compare two version of CagriSema injected by two different types of injection devices. Which treatment participants get is decided by chance using a computer program, so neither participants nor study staff will know which treatment is given. The study will last for about one year.

Status (registry)
Withdrawn
Phase (registry)
Phase 3
Study type
Interventional
Enrollment
0 (actual)
First submitted
21 Jan 2026
Start date
22 Jun 2026
Primary completion date
29 Nov 2027
Lead sponsor
Novo Nordisk A/S
Diseases
Obesity
NCT number
NCT07357766
EudraCT number
2024-520448-41

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Previous exposure to CagriSema in a clinical study.

Other illness

  • History of type 1 or type 2 diabetes.

Lab values

  • Glycosylated haemoglobin (HbA1c) >= 6.5 % (48 millimoles per mole [mmol/mol]) as measured by the central laboratory at screening.

Who the study is looking for

  • Male or female (sex at birth)
  • Age 18 years or above at the time of signing the informing consent.
  • Body Mass Index (BMI) is greater than or equal to (>= ) 30.0 kilograms per square metre (kg/m\^2) or BMI >= 27.0 kg/m\^2 with the presence of at least one obesity-related complication including, but not limited to, hypertension, dyslipidaemia, obstructive sleep apnoea or cardiovascular disease.

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (115)

Sites in registry order. Save your city in your profile to sort them by distance.

SiteCityCountrySite status
IPSMC - Dr. Nikolay Kostadinov EOODBurgasBulgariaUnknown status
Medical Center Viva Feniks OODDobrichBulgariaUnknown status
IPSOMC Dr. Miglena Rizova Ltd.KyustendilBulgariaUnknown status
UMHAT Pulmed OOD - Plovdiv, Department of EndocrinologyPlovdivBulgariaUnknown status
DCC Iztok EOODPlovdivBulgariaUnknown status
UMHAT Sveti Georgi EAD, Plovdiv, Clinic of EndocrinologyPlovdivBulgariaUnknown status
MHAT Sveta Karidad EADPlovdivBulgariaUnknown status
Medical Centre Razgrad OODRazgradBulgariaUnknown status
DCC VII - Sofia EOOD, EndocrinologySofiaBulgariaUnknown status
Diagnostic-Consultative Anti-Aging and Rejuvenation Center Hill Clinic EADSofiaBulgariaUnknown status
AIPSMC Dr. Artin Magardichyan EOODVarnaBulgariaUnknown status
DCC Mladost M- Varna, OODVarnaBulgariaUnknown status
Medical Center Medical Plus EOODVarnaBulgariaUnknown status
Luzerner KantonsspitalLucerneSwitzerlandUnknown status
Kantonsspital OltenOltenSwitzerlandUnknown status
Stoffwechselzentrum St. GallenSankt GallenSwitzerlandUnknown status
Diabetes Adipositas Zentrum ZürichZollikerbergSwitzerlandUnknown status
Sanos Clinic GandrupGandrupDenmarkUnknown status
Sanos Clinic VejleVejleDenmarkUnknown status
Regionshospitalet Viborg - Karkirurgisk AfsnitViborgDenmarkUnknown status
General Hospital Of Athens G Gennimatas - Department of EndocrinologyAthensGreeceUnknown status
251 Air Force General Hospital - Department of Endocrinology & DiabetesAthensGreeceUnknown status
Laiko General Hospital Of Athens - A' Propaedeutic Clinic of Internal Medicine-Diabetes CentreAthensGreeceUnknown status
Athens Medical Center S.A. (Iatriko Athinon) - Diabetes and Obesity UnitMarousiGreeceUnknown status
Athens Medical Center S.A. (Iatriko P. Falirou) - Diabetes and Clinical Research CenterPalaió FáliroGreeceUnknown status
Thermi Clinic S.A. - Diabetes and Internal Medicine DepartmentThessalonikiGreeceUnknown status
General Hospital Of Thessaloniki G Gennimatas - Internal Medicine ClinicThessalonikiGreeceUnknown status
ClinDiab Egészségügyi Szolgáltató és Kereskedelmi Kft.BudapestHungaryUnknown status
Belinus Bt.DebrecenHungaryUnknown status
Debreceni EgyetemDebrecenHungaryUnknown status
Borbánya Praxis E.Ü. Kft.NyíregyházaHungaryUnknown status
Arina Trial Research kft.OrosházaHungaryUnknown status
Szegedi Tudomanyegyetem St Györgyi Albert Klinikai KözpontSzegedHungaryUnknown status
Hospital Canselor Tuanku Muhriz UKMCherasMalaysiaUnknown status
Hospital Pulau PinangGeorge TownMalaysiaUnknown status
Hospital Raja Perempuan Zainab IIKota BharuMalaysiaUnknown status
Klinik Kesihatan Kuala KedahKuala KedahMalaysiaUnknown status
University Malaya Medical CentreLembah PantaiMalaysiaUnknown status
Hospital MelakaMalaccaMalaysiaUnknown status
Hospital MiriMiriMalaysiaUnknown status
Klinik Kesihatan KuangRawangMalaysiaUnknown status
Hospital Queen Elizabeth IISabak BernamMalaysiaUnknown status
Hospital Seri ManjungSeri ManjungMalaysiaUnknown status
University Technology MARA (UiTM) - Sg BulohSungai BulohMalaysiaUnknown status
Gabinet Leczenia Otylosci i Chorob DietozaleznychBialystokPolandUnknown status
Centrum Medyczne Kermed Renata Bijata-Bronisz I Ewa Kowalinska Sp. j.BydgoszczPolandUnknown status
Niepubliczny Zakład Opieki Zdrowotnej BIF-MED S.C. Arkadiusz Wawiernia, Mariola Roykiewicz, Rafał RoykiewiczBytomPolandUnknown status
NZOZ Mediart Centrum Zdrowia MatarniaGdanskPolandUnknown status
Synexus Polska Sp. z o.o. Oddzial w GdanskuGdanskPolandUnknown status
ID Clinic Arkadiusz PisulaMysłowicePolandUnknown status
Synexus Polska Sp. z o.o., Oddzial w WarszawieWarsawPolandUnknown status
Clinical Best Solutions Sp. Z O.O. Sp.K.WarsawPolandUnknown status
Kardio Life - Tomasz BorkowskiWłocławekPolandUnknown status
Velocity Nova Sp. z o.o.ZamośćPolandUnknown status
Prywatna Praktyka Lekarska Anna ChudobaŻyrardówPolandUnknown status
ULS De Braga, E.P.E. - Hospital de Braga_Centro Clínico AcadémicoBragaPortugalUnknown status
ULS Do Alto Ave, E.P.E - HSOG_Centro de Investigação ClínicaGuimarãesPortugalUnknown status
Hospital São Francisco, S.A_EECCLeiriaPortugalUnknown status
APDP - Associação Protectora dos Diabéticos de PortugalLisbonPortugalUnknown status
Affidea Montijo - UCardioMontijoPortugalUnknown status
Cardiolima Centro Diagnostico Cardio-Pulmonar De Ponte De Lima LdaPonte de LimaPortugalUnknown status
Thera Card S.R.LBrasovRomaniaUnknown status
Kilostop Junior SRLBucharestRomaniaUnknown status
SC Diamed Obesity SRLGalatiRomaniaUnknown status
ARCADIA POLICLINIC SRLIasiRomaniaUnknown status
Spital Judetean De Urgenta Satu MareSatu MareRomaniaUnknown status
Sc Gensan Srl/Policlinica AstraSibiuRomaniaUnknown status
Spitalul Clinic Judetean de Urgenta Targu MuresTârgu MureşRomaniaUnknown status
MED-CENTRUM, s.r.o.MartinSlovakiaUnknown status
KARDIOMED NZ s.r.o.Nové ZámkySlovakiaUnknown status
SVAJDLEROVA, s.r.o.PrešovSlovakiaUnknown status
ENRIN, s.r.o.Rimavská SobotaSlovakiaUnknown status
DIAB s.r.o.RožňavaSlovakiaUnknown status
Siriraj HospitalBangkokThailandUnknown status
Ramathibodi HospitalBangkokThailandUnknown status
RIHES-CMU_Research Institute for Health SciencesChiang MaiThailandUnknown status
Maharaj Nakorn Chiang MaiChiang MaiThailandUnknown status
Hat Yai HospitalHat YaiThailandUnknown status
Thammasat Hospital_CRCPathum ThaniThailandUnknown status
Ditmanson Medical Foundation Chia-Yi Christian HospitalChiayi CityTaiwanUnknown status
Kuang Tien General HospitalTaichungTaiwanUnknown status
Chi Mei Medical CenterTainanTaiwanUnknown status
Taipei Municipal Wan Fang Hospital_Division of Endocrinology & MetabolismTaipeiTaiwanUnknown status
Elligo Clin Res CentreAustinUnited StatesUnknown status
Uni of Alabama at BirminghamBirminghamUnited StatesUnknown status
Anointed Nephrology & HTN, LLCBrookhavenUnited StatesUnknown status
PGM Research of Christie ClinicChampaignUnited StatesUnknown status
University of Texas Southwestern Medical CenterDallasUnited StatesUnknown status
Tribe Clinical Research LLCGreerUnited StatesUnknown status
Forefront Med Res Inst PLLCHarlingenUnited StatesUnknown status
Advanced Investigative Medicine, Inc.HawthorneUnited StatesUnknown status
NextPhase ResearchHollywoodUnited StatesUnknown status
Rocky Mountain Diabetes and Osteoporosis CenterIdaho FallsUnited StatesUnknown status
Palm Research Center IncLas VegasUnited StatesUnknown status
Walker Family CareLittle RiverUnited StatesUnknown status
Oceane 7 Medical & Research Center, Inc.MiamiUnited StatesUnknown status
TPMG Clinical ResearchNewport NewsUnited StatesUnknown status
Weill Medical College of Cornell UniversityNew YorkUnited StatesUnknown status
Alliance for Multispecialty ResearchNormanUnited StatesUnknown status
Capital Clin Res Ctr,LLCOlympiaUnited StatesUnknown status
Cahaba ResearchPelhamUnited StatesUnknown status
Southern Cal Clinical ResearchSanta AnaUnited StatesUnknown status
EBGS Clinical Research Center, LLCSnellvilleUnited StatesUnknown status
Encompass Clinical Research_Spring ValleySpring ValleyUnited StatesUnknown status
ForCare Clinical ResearchTampaUnited StatesUnknown status
Arcturus HC PLC Troy Med ResTroyUnited StatesUnknown status
Rophe Adult & Pediatric MedicineUnion CityUnited StatesUnknown status
Chase Medical Research, LLCWaterburyUnited StatesUnknown status
Dr T PadayacheeDurbanSouth AfricaUnknown status
Dr Vawda's siteDurbanSouth AfricaUnknown status
Dr Moosa's RoomsGautengSouth AfricaUnknown status
Soweto Clinical Trial CentreJohannesburgSouth AfricaUnknown status
Ezintsha Research CentreJohannesburgSouth AfricaUnknown status
Clinical Research Institute of South AfricaKwaDukuzaSouth AfricaUnknown status
Dr A Jacovides and Partners IncMidrandSouth AfricaUnknown status

Are you the coordinator? Confirm the details

In 14 countries, 115 sites

United States 25, Bulgaria 13, Malaysia 11, Poland 11, Greece 7, Romania 7, South Africa 7, Hungary 6, Portugal 6, Thailand 6, Slovakia 5, Switzerland 4, Taiwan 4, Denmark 3

The registry text, word for word

This page is information, not medical advice. Discuss any trial with your doctor.