Searching for markers of hidden obesity in young women with normal body weight
Looks for blood and vessel markers of excess body fat in normal-weight women.
Plain-language title generated from the registry record
Registry title: Metabolic Obesity in Normal Weight (MONW): Diagnostic Markers Stud
Key facts
- Where
- Szczecin, PolandSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 35 years old?
Source: NCT07358533, who can take part
Where in Poland
- Pomeranian Medical University in SzczecinSzczecin, PolandNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Pomeranian Medical University Szczecin
- Trial code
- NCT07358533
- Record updated
- 23 January 2026
- Original description
Metabolically Obese Normal Weight (MONW) represents a phenotype affecting individuals with a normal Body Mass Index (BMI) but characterized by excessive adipose tissue accumulation. This condition is associated with increased cardiovascular risk, insulin resistance, and endothelial dysfunction, yet remains underdiagnosed.Read full original descriptionShow less
Disorders Hidden Under the Guise of BMI - Metabolic Obesity in People With Normal Body Weight (MONW) - the Search for Diagnostic Markers and Its Consequences for Health
Metabolically Obese Normal Weight (MONW) represents a phenotype affecting individuals with a normal Body Mass Index (BMI) but characterized by excessive adipose tissue accumulation. This condition is associated with increased cardiovascular risk, insulin resistance, and endothelial dysfunction, yet remains underdiagnosed.
This observational longitudinal study aims to comprehensively evaluate the relationship between excessive adipose tissue deposition, endothelial dysfunction, and asprosin concentrations in young women. The study will recruit 176 healthy women aged 18-35 years with normal BMI (<25 kg/m²). Participants will be divided into two groups based on body fat percentage (PBF) assessed by dual-energy X-ray absorptiometry (DXA): the MONW group (PBF ≥ 35.78%) and the Control group (PBF < 35.78%).
The specific objectives of the study include:
* Assessment of vascular endothelial function using flow-mediated dilation (FMD) of the brachial artery. * Evaluation of asprosin as a novel biomarker in the MONW phenotype. * Analysis of biochemical indices including asymmetric dimethylarginine (ADMA) and von Willebrand factor (vWF). * Advanced metabolomic profiling to identify metabolic signatures.
Participants will undergo anthropometric measurements, body composition analysis (DXA), and blood sampling for biochemical and hormonal analyses. The study aims to develop predictive models for early cardiovascular risk detection in normal-weight individuals.
Inclusion: Written, informed consent to participate in the research; Gender: Female; Age 18-35 years; BMI in the range of 18.5-25 kg/m².
Exclusion: Hormone therapy and/or use of hormonal contraceptives; Metal or silicone implants (contraindication for DXA/body composition accuracy); Use of hypolipemic, antihypertensive, antiglycemic, or insulin medications; Thyroid disease; Eating disorders; Polycystic ovary syndrome (PCOS); Acute and/or chronic illnesses; Type I or II diabetes, dyslipidemia, hypertension; Pregnancy or breastfeeding; Smoking; Vitamin and/or mineral supplementation.