Studying heart tissue samples to understand different heart muscle diseases
Examines heart biopsy samples to find molecular patterns in people with heart muscle disease.
Plain-language title generated from the registry record
Registry title: Multimodal Analysis of Endomyocardial Biopsies
Key facts
- Where
- Essen, GermanySee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults who already need an endomyocardial biopsy (a small heart tissue sample) as part of their normal care. One extra sample is taken for research.
- Age
- Over 18 years
- Sex
- All sexes can join.
Main reasons for not taking part
- No medical reason for an endomyocardial biopsy
- Pregnant
- Cannot give informed consent
- Women who could become pregnant and are not using adequate contraception
Read by machine on 13 November 2026.
Where in Germany
- Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center Essen, University Hospital Essen, GermanyEssen, GermanyContact: Lars Michel, PD Dr. med.Taking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- University Hospital, Essen
- Trial code
- NCT07359690
- Record updated
- 22 January 2026
- Original description
The goal of this observational study is to pursue a multimodal approach to identify the molecular signatures and immune signalling molecules of various myocardial diseases and thereby contribute to improving diagnosis and therapy.Read full original descriptionShow less
Multimodal Analysis of Endomyocardial Biopsies
The goal of this observational study is to pursue a multimodal approach to identify the molecular signatures and immune signalling molecules of various myocardial diseases and thereby contribute to improving diagnosis and therapy.
The main aim is:
-Identification of molecular profiles (e.g., proteome, lipidome, metabolome) and immune signalling profiles that are specifically associated with different myocardial diseases and the post-heart transplantation course.
Participants already receiving an endomyocardial biopsy as part of their regular medical care will be enrolled. An additional biopsy sample will be taken for the above mentioned research.
Inclusion: Patients aged >18 years with a clinical indication for endomyocardial biopsy; Patients capable of providing informed consent who have signed the consent form for participation in the study.
Exclusion: Patients without a clinical indication for endomyocardial biopsy (EMB); Pregnant individuals; Patients incapable of providing informed consent; Women of childbearing potential who are not using adequate contraception.