Blackcurrant Supplement for Bone Health and Gut Bacteria After Menopause
Tests blackcurrant extract on bone density and gut bacteria in postmenopausal women.
Plain-language title generated from the registry record
Registry title: Blackcurrants Modify Gut Microbiota and Reduce Osteoporosis Risk in Postmenopausal Females
Key facts
- Where
- Storrs, United StatesSee the site
- Phase
- Phase 1
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 45 and 70 years old?
Source: NCT07365514, who can take part
Where in United States
- University of Connecticut, Department of Nutritional SciencesStorrs, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Connecticut
- Trial code
- NCT07365514
- Record updated
- 23 July 2026
- Original description
The goal of this clinical trial is to evaluate the effects of blackcurrant (BC) supplementation on changes in bone density and gut microbiome composition in postmenopausal females.Read full original descriptionShow less
Blackcurrants Mitigate Postmenopausal Bone Loss Through Gut Microbiota-Bone Axis: A Randomized Clinical Trial Coupled With a Multi-Omics Approach to Inform Precision Nutrition
The goal of this clinical trial is to evaluate the effects of blackcurrant (BC) supplementation on changes in bone density and gut microbiome composition in postmenopausal females.
Inclusion: postmenopausal (defined as no more than 10 years since final menstrual cycle) females aged 45-70 years; not on hormone replacement therapy for at least one year before initiation of the study; maintaining normal exercise level (< 7 hours/week) and willing to avoid exercise for 24 hours prior to blood and stool sampling; willing to ingest a dietary blackcurrant supplement or placebo (up to 1,176 mg/day, three 392mg capsules); willing to avoid other dietary supplements for the duration of the study; willing to avoid intake of foods extremely rich in anthocyanins and fermented dairy products containing viable Bifidobacteria or Lactobacilli; willing to have three blood draws, three stool collections, and three bone scans.
Exclusion: taking anabolic agents such as parathyroid hormone or growth hormone, or steroid within 3 months before the start of the study; those with planned surgery during the study period or within 2 weeks of ending the intervention; history of cardiovascular disease, osteoporosis, metabolic bone disease, cancer, diabetes mellitus, arthritis, or other chronic inflammatory diseases; taking medications that alter bleeding (such as antiplatelets or anticoagulants) or those with a bleeding disorder; those with sensitivities or allergies to any of the ingredients for the placebo (rice powder); taking prescription medications known to alter bone and calcium metabolism; current smokers; alcohol consumption exceeding 2 drinks/day (approximately 14g of ethanol per drink) or a total of 12/week; planning a procedure that includes iodine, barium or nuclear medicine isotopes within the study period; UConn students and/or employees who any key personnel teach or who report to any key personnel; study key personnel, partners of key personnel, or dependents/relatives of any key personnel.