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How people with idiopathic REM sleep behavior disorder perceive pain

Looks at pain perception in adults with REM sleep behavior disorder.

Key facts

Who runs it
University Hospital, Toulouse
Where
Toulouse, FranceSee the site
Trial code
Registry title
Pain Assessment in Patients With Idiopathic Rapid Eye Movement (REM) Sleep Behaviour Disorder
Status
Recruiting
People taking part
24 people, planned
Started
24 Feb 2026
Planned end
Aug 2026
Type of study
Interventional, 2 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • Thermo test pain
  • Pain questionnaires
  • No motors symptoms evaluations
Record updated
1 May 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with idiopathic REM sleep behaviour disorder (iRBD) confirmed by a sleep study. A control group has narcolepsy type 1 with REM sleep behaviour disorder. The trial looks at how people feel pain.

Age
18 years or older
Sex
Men and women can join.
Disease stage
iRBD confirmed by polysomnography (a sleep study), with no diagnosis of Parkinson's disease or another neurodegenerative disease. The control group has narcolepsy type 1 with REM sleep behavior disorder confirmed by polysomnography.

Main reasons for not taking part

  • Diagnosed Parkinson's disease, dementia with Lewy bodies or multiple system atrophy
  • Severe depression according to DSM V
  • Cannot complete the study procedures or questionnaires

The registry criteria, word for word

Show all 9 criteriaShow less

Who can take part

  • Diagnosed with iRBD confirmed by polysomnography
  • No clinical diagnosis of Parkinson's disease or other diagnosis of neurodegenerative disease
  • Ability to understand and complete study procedures and questionnaires; Control group:
  • Diagnosed with narcolepsy type 1
  • Coexisting REM sleep behavior disorder confirmed by polysomnography
  • Ability to understand and complete study procedures and questionnaires

Who cannot take part

  • Diagnosed Parkinson's Disease, dementia with Lewy bodies or multiple system atrophy
  • Severe depression according to Diagnostic and Statistical Manual of Mental Disorders (DSM V)
  • Inability to complete study procedures or questionnaires

Where in France

  • Centre Expert Parkinson Hôpital Pierre Paul Riquet Place du Docteur BaylacToulouse, FranceContact: Emeline MullerTaking people

About the trial

What the trial wants to find out

Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, with over 12 million patients expected globally by 2040. The disease is currently diagnosed at the appearance of motor symptoms, but by then, over 60% of striatal dopaminergic neurons have already been destroyed. Prodromal symptoms such as idiopathic REM Sleep Behavior Disorder (iRBD), anosmia, mood disorders and constipation appear earlier and are listed as criteria for a prodromal PD diagnosis. Identifying early signs is critical to initiate neuroprotective treatments as early as possible. While pain is prevalent and highly disabling in early PD, no data are currently available on pain perception in iRBD patients, whose condition is of the main risk factor for PD development.

The 2 groups in the trial

  • Idiopathic REM sleep Behavior disorder (iRBD) GroupTreatment being tested

    Patients who have an idiopathic REM sleep Behavior Disorder

    Treatment: Thermo test pain, Pain questionnaires, and No motors symptoms evaluations

  • Idiopathic REM Sleep Bhavior Disorder (iRBD) + narcolepsy type 1Existing treatment, for comparison

    patients who have an iRBD and who have type 1 narcolepsy

    Treatment: Thermo test pain, Pain questionnaires, and No motors symptoms evaluations

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Pain Assessment in Patients With Idiopathic REM Sleep Behaviour Disorder
Plain-language title
How people with idiopathic REM sleep behavior disorder perceive painGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
1 May 2026