NCT07366879Recruiting
Exercise Intervention as an Adjunct to Medical Therapy in Newly Diagnosed Patients With Pulmonary Arterial Hypertension
Randomised Controlled Trial of Exercise Intervention as an Adjunct to Medical Therapy in Newly Diagnosed Patients With Pulmonary Arterial Hypertension
Source: ClinicalTrials.gov · Last updated 13 May 2026
Brief summary (registry, in English)
The goal of this clinical trial is to learn if an exercise programme started shortly after diagnosis improves the fitness and mental wellbeing of patients with pulmonary hypertenion over and above medication alone. It will also learn about whether extra support can help patients keep up with exercise in the long term. The main questions it aims to answer are: * Doe exercise improve how far patients can walk over six minutes * Does exercise improve quality of life scores * Does exercise improve mental health scores * Does extra support after an exercise programme help patients to continue exercising in the long term Researchers will compare the exercise programme to a control group (a group of similar patients who do not receive the exercise programme) to see the effect that exercise has. Participants in the exercise programme group will: * Undergo an exercise programme for 12 weeks, starting around 3 months after their diagnosis * They will undertake the exercise programme at home, remotely supervised by the research team with regular contact * Visit the clinic at the end of the programme for checkups and tests * Keep a diary of their exercise and how they are feeling Participants in the control group will: -Still undergo the exercise programme, but this will happen at a delayed time, starting around 6 months after diagnosis, to allow for a comparison between the two groups. Following completion of the exerise programme: * Half of participants will receive extra support to help them continue to exercise * The other half will not receive any additional support * All patients will be reviewed 1 year following the completion of their exercise programme to monitor their ongoing exercise levels.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 7 Jan 2026
- Start date
- 2 Apr 2026
- Primary completion date
- Aug 2027
- Lead sponsor
- Golden Jubilee National Hospital
- NCT number
- NCT07366879
What you commit to
- Study type: Interventional
- Planned participants: 40
- From 2 Apr 2026 to the primary completion date, Aug 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Planned treatment with a research trial medication during the study timeframe
- Severe concurrent medical condition that would prevent participation in study procedures
Other illness
- Diagnosis with pulmonary hypertension of any other cause
- Group II (PH due to left heart disease)
- Group III (PH due to hypoxic lung disease)
- Operable group IV (PH due to chronic thromboembolic disease amenable to surgical treatment)
- Group V (unclear and/or multifactorial elements).
- Patients with syncopal episodes felt to be related to pulmonary hypertension at time of exercise intervention initiation.
Other
- Consenting clinician and/or patient concern regarding the patient's safety in performing a home-based exercise programme
- Life expectancy \<3 months
Who the study is looking for
- Aged 18-years-old and above
- Diagnosed with pulmonary hypertension (group I and non-operable group IV) by right heart catheterisation showing:
- a baseline mean pulmonary artery pressure \>20mmHg
- pulmonary vascular resistance \>2 Wood Units
- pulmonary capillary wedge pressure \<15mmHg
- Able to provide written informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Golden Jubilee National Hospital Coordinator of this site? Confirm its status | Glasgow | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.