Neuropathic Pain in Knee Osteoarthritis: Pain Severity and Functional Status
Key facts
- Where
- Istanbul, TürkiyeSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 70 years old?
Source: NCT07367126, who can take part
Where in Türkiye
- Istanbul Physical Medicine and Rehabilitation Training and Research HospitalIstanbul, TürkiyeContact: Eser Kalaoglu, M.D.Taking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
- Trial code
- NCT07367126
- Record updated
- 26 January 2026
- Original description
Osteoarthritis (OA) is a degenerative joint disease characterized by structural changes such as cartilage loss and osteophyte formation, leading to functional limitations and disability. Pain in knee OA involves a complex pathophysiological structure including both nociceptive and neuropathic mechanisms. Identifying the neuropathic pain component is clinically significant for improving quality of life and functional recovery. This cross-sectional controlled clinical study aims to determine the prevalence of neuropathic pain in patients with knee OA and evaluate its impact on pain severity and functional status. Patients will be categorized based on the Douleur Neuropathique 4 (DN4) questionnaire and assessed using various pain and functional scales.Read full original descriptionShow less
Presence of Neuropathic Pain in Knee Osteoarthritis: Relationship Between Pain Severity and Functional Status
Osteoarthritis (OA) is a degenerative joint disease characterized by structural changes such as cartilage loss and osteophyte formation, leading to functional limitations and disability. Pain in knee OA involves a complex pathophysiological structure including both nociceptive and neuropathic mechanisms. Identifying the neuropathic pain component is clinically significant for improving quality of life and functional recovery. This cross-sectional controlled clinical study aims to determine the prevalence of neuropathic pain in patients with knee OA and evaluate its impact on pain severity and functional status. Patients will be categorized based on the Douleur Neuropathique 4 (DN4) questionnaire and assessed using various pain and functional scales.
Inclusion: Diagnosed with Knee OA according to ACR criteria; Knee pain for more than 3 months; Voluntary participation.
Exclusion: History of surgical intervention in the affected knee; History of trauma to the affected knee within the last 6 months; History of intra-articular injections (e.g., corticosteroids, hyaluronic acid, PRP) or physical therapy involving the affected knee within the last 6 months; Presence of severe psychiatric disorders such as severe depression, anxiety disorder, or psychosis; Diagnosis of central nervous system diseases, including Parkinson's disease or multiple sclerosis; Severe cognitive impairment; Chronic decompensated cardiac, renal, or hepatic failure; Severe psychiatric, neurological, or kognitive disorders; Decompensated cardiac, renal, or hepatic failure; Diagnosis of inflammatory arthritis, such as Rheumatoid Arthritis or Ankylosing Spondylitis.