Clinical Management Strategies for Patients With Cirrhosis and Esophagogastric Varices Complicated by Early-stage Upper Gastrointestinal Cancer
Key facts
- Who runs it
- Renmin Hospital of Wuhan University
- Where
- China1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 206 people enrolled
- Started
- 1 Aug 2023
- Ended
- 1 Dec 2025
- Type of study
- Observational, 2 groups
- Record updated
- 26 January 2026
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 9 criteriaShow less
Who can take part
- The cirrhosis group:
- Age >18 years
- A clinical diagnosis of liver cirrhosis
- Endoscopically confirmed EGV; The noncirrhosis group:
- Age > 18 years
- With early-stage upper gastrointestinal cancer but without cirrhosis
Who cannot take part
- Concomitant end-stage disease of major organs (e.g., active malignancy, heart failure, respiratory failure) or an American Society of Anesthesiologists (ASA) physical status classification ≥ III
- Previous surgery for cirrhosis, EGV, or other upper gastrointestinal lesions
- Incomplete clinical records
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
Managing early-stage upper gastrointestinal cancer in patients with liver cirrhosis and esophagogastric varices (EGV) poses substantial clinical challenges. Although endoscopic submucosal dissection (ESD) is an established treatment for these early cancers, its efficacy and safety in this high-risk population are poorly defined. Therefore, this study aims to investigate optimal screening and treatment strategies for early-stage upper gastrointestinal cancer in cirrhotic patients with EGV. Perioperative outcomes were compared between the two groups.
The 2 groups in the trial
- cirrhosis group
cirrhotic patients with EGV and early-stage upper gastrointestinal cancer 问who underwent ESD
- noncirrhosis group
Patients who underwent ESD without cirrhosis and EGV
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Clinical Management Strategies for Patients With Cirrhosis and Esophagogastric Varices Complicated by Early-stage Upper Gastrointestinal Cancer: a Multicenter Retrospective Cohort Study
- Record updated
- 26 January 2026