Comparing Gene-Informed and Standard Diet Advice for Weight Loss
Compares diet advice guided by genetic information with standard diet advice in adults with overweight.
Key facts
- Who runs it
- Metropolitan College
- Where
- Marousi, GreeceSee the site
- Trial code
- Registry title
- Comparison of Genotype-Based Dietary Counseling Versus Standard Dietary Counseling on Weight Loss and Fat Mass Reduction
- Status
- Recruiting
- People taking part
- 88 people, planned
- Started
- 15 Dec 2025
- Expected to end
- Mar 2027
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Genotype-Based Dietary Counseling
- Standard Dietary Counseling
- Record updated
- 28 January 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults who are overweight and can take part in dietary counseling. It compares counseling based on genes with standard dietary counseling.
- Age
- 18 to 65 years
- Sex
- All sexes can join.
- Disease stage
- Body mass index (BMI) of 25 kg/m² or higher.
- Earlier treatment
- Cannot have taken weight-loss medicines, or been in a structured weight-loss program in the previous 3 months.
Main reasons for not taking part
- Current weight-loss medicines such as GLP-1 receptor agonists or appetite suppressants
- Structured weight-loss program in the previous 3 months
- Medicines that strongly affect body weight, such as systemic corticosteroids, antipsychotics or thyroid medicines
- Pregnancy or breastfeeding
- Conditions affecting weight or metabolism, such as untreated thyroid disease, severe gut disorders or hormone disorders
The registry criteria, word for word
Show all 9 criteriaShow less
Who can take part
- Adults aged ≥18 years
- Body mass index (BMI) ≥25 kg/m²
- Greek-speaking (able to read and understand Greek and provide informed consent)
- Willing and able to participate in dietary counseling and study assessments for the duration of the study
Who cannot take part
- Current use of pharmacological treatments for weight loss, including but not limited to GLP-1 receptor agonists, appetite suppressants, or other anti-obesity medications
- Participation in any structured weight-loss intervention or program within the previous 3 months, including commercial weight-loss programs or medically supervised dietary interventions
- Use of medications known to significantly affect body weight or body composition, such as systemic corticosteroids, antipsychotic medications, or medications for thyroid disorders
- Presence of medical conditions that may affect body weight, metabolism, or nutritional status, including untreated thyroid disease, severe gastrointestinal disorders, or endocrine disorders
- Pregnancy or lactation
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Where in Greece
- Dietetics Department, School of Health Sciences, Metropolitan CollegeMarousi, GreeceContact: Angeliki Kapellou, PhDTaking people
About the trial
What the trial wants to find out
This study aims to compare the effects of genotype-based dietary counseling with standard dietary counseling based on general recommendations on weight loss and reduction of body fat. Participants will receive individualized dietary guidance either informed by genetic information or based on conventional dietary guidelines. Changes in body weight and body composition will be assessed over the course of the intervention.
The 2 groups in the trial
- Genotype-Based Dietary CounselingTreatment being tested
Participants in this arm will receive dietary counseling tailored according to their genetic profile. Dietary recommendations will be provided by qualified nutrition professionals and will be based on individual genetic information in combination with standard nutritional principles. The counseling will be delivered over the course of the intervention period.
- Standard Dietary CounselingExisting treatment, for comparison
Participants in this arm will receive dietary counseling based on general dietary guidelines and standard nutritional recommendations. Counseling will be provided by qualified nutrition professionals over the course of the intervention period, without the use of genetic information.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Comparison of Genotype-Based Dietary Counseling Versus Standard Dietary Counseling on Weight Loss and Fat Mass Reduction
- Plain-language title
- Comparing Gene-Informed and Standard Diet Advice for Weight LossGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT07368777, who can take part
- Record updated
- 28 January 2026