Tracking Prostate Lesion Changes on Repeated MRI Scans
Tests repeated prostate MRI scans in men whose first biopsy showed no serious prostate cancer.
Plain-language title generated from the registry record
Registry title: Evolution of Lesions in Repeated Biparametric Prostate Magnetic Resonance Imaging
Key facts
- Where
- Kuopio, FinlandSee the site
Where in Finland
- Kuopio University HospitalKuopio, FinlandTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Eastern Finland
- Trial code
- NCT07369570
- Record updated
- 24 February 2026
- Original description
The goal of this clinical trial is to prospectively investigate the evolution of lesions in biparametric magnetic resonance imaging (bpMRI) of the prostate in men with no clinically significant prostate cancer (csPCa) in their initial biopsy. The main questions it aims to answer are:Read full original descriptionShow less
A Prospective Study of the Evolution of Lesions in Repeated Biparametric Prostate Magnetic Resonance Imaging
The goal of this clinical trial is to prospectively investigate the evolution of lesions in biparametric magnetic resonance imaging (bpMRI) of the prostate in men with no clinically significant prostate cancer (csPCa) in their initial biopsy. The main questions it aims to answer are:
Does lesion progression in bpMRI predict a diagnosis of csPCa in per-protocol follow-up biopsies?
What are the radiological and clinical risk factors for csPCa in per-protocol follow-up biopsies?
Inclusion: Suspicion of a local prostate cancer; Patient have 1-2 PI-RADS 3-5 lesion/lesions in biparametric prostate MRI, with no ISUP 2-5 prostate cancer in an initial systematic or lesion-targeted (at least two biopsy cores per lesion) biopsy; Prostate biopsies can be taken via transrectal approach in an outpatient clinic; An estimated life expentancy exceeding 10 years; The patient is cooperative, fluent in Finnish and understands the significance of the study; The patient signs an informed consent form approved by the ethics committee.
Exclusion: The patient had undergone prostate biopsies prior to the biopsies that led to recruitment for the current study; The physician's suspicion of a locally advanced or a high risk prostate cancer. Absolute exclusion criteria are PSA >20 ng/ml or T4 staged prostate finding MRI or clinical examination; Deep immunosuppression due to organ transplant, hematologic disease, or related causes; Any treatment given for prostate cancer diagnosed in initial biopsy; Seriuos infectious or non-infectious complication after initial biopsy; Hip prosthesis or any other object in the pelvic area that affects high-quality MRI; Claustrophobia or other absolute or relative contraindication for high-quality MRI.