VentricuLostomy AssoCiaTed InfeCtions (LACTIC): Focus on CSF Lactate and Sampling Site
Key facts
- Where
- Copenhagen, DenmarkSee the site
Where in Denmark
- RigshospitaletCopenhagen, DenmarkContact: Pernille Nielsen, Medical doctorTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Copenhagen University Hospital, Rigshospitalet
- Trial code
- NCT07380477
- Record updated
- 2 February 2026
- Original description
This observational study involving patients with acute brain injury undergoing treatment with an external ventricular drain consists of three subprojects, aiming to:Read full original descriptionShow less
CSF Lactate and Ventriculostomy Associated Infections in Patients With Acute Brain Injury - a Prospective, Observational Cohort Study.
This observational study involving patients with acute brain injury undergoing treatment with an external ventricular drain consists of three subprojects, aiming to:
1. investigate various biomarkers, with a primary focus on the development of cerebrospinal fluid lactate in relation to ventriculostomy-associated infection; 2. compare proximal and distal sample results obtained from an external ventricular drain; 3. describe the natural progression of various biomarkers in blood and cerebrospinal fluid following acute brain injury.
Inclusion: Age >18 years; EVD in situ; Admission to the neuro-ICU or neurosurgical step-down unit at Rigshospitalet, Denmark; Diagnosis of acute brain injury categorized as traumatic brain injury, subarachnoid haemorrhage, intracranial haemorrage, intraventricular haemorrhage.
Exclusion: Patients with brain injury due to existing brain infection (e.g., meningitis, intracranial empyema or abscess, encephalitis); Patients with primary or secondary brain cancer; Patient or closest relatives do not understand written and spoken Danish or English; Patients transferred to Rigshospitalet with an EVD; Patients with existing ventriculoperitoneal or ventriculoatrial shunt at the time of admission; Patients died or in palliative care.