Cervical Plexus Hydrodissection With D5W Versus NS for Treatment-Resistant PTSD
Key facts
- Who runs it
- Dr. Dean Reeves Clinic
- Where
- Lexington, Madison, and Portland, United StatesSee the 4 sites
- Trial code
- Status
- Recruiting
- Phase
- Phase 4
- People taking part
- 50 people, planned
- Started
- 16 May 2026
- Expected to end
- 1 Apr 2030
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Dextrose 5% in water bilateral injection
- Normal saline bilateral injection
- Record updated
- 9 November 2026
Who can take part
- Age
- 19 years to 90 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 23 criteriaShow less
Who can take part
- Inclusion Criteria:
- Not involved in another study of PTSD treatment
- Reliable transportation
- Comfortable with computers
- Tried 2 or more medications for treatment of PTSD symptoms
- Tried 2 or more non-medication treatments for PTSD symptom
- No known life-threatening illness
- Not taking daily narcotics
- Not having 3 or more alcoholic drinks on an average day
- No active suicidal plans
- No major surgery plans
- No major life stress that might interfere with completing study
- Symptoms for more than 1 year
- Not planning to move for next 18 months
- Living within an hour of Portland, OR, Madison, WI, or Lexington, KY
- Wiling to provide 2 email and 2 phone contact methods
- Willing to answer questions on multiple occasions over the course of a year
- Willing to be assigned to 3 months of usual care treatment
- No diagnosis of schizophrenia, Borderline Personality Disorder, or Bipolar Disorder
- No severe needle phobia
- Chronic pain ≤ 5/10
- PCL-C score ≥ 50
Who cannot take part
- -
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 19 and 90 years old?
Where in United States
- Wellward MedicalLexington, United StatesContact: Danesh Mazloomdoost, M.D.Not yet recruiting
- Medical Procedures of WisconsinMadison, United StatesContact: Eric Phillippi, M.D.Taking people
- NW RegenPortland, United StatesContact: Ryan R Wood, N.D., D.C.Taking people
- Paul Johnson, MD.Portland, United StatesContact: Paul W Johnson, D.O.Taking people
About the trial
What the trial wants to find out
PTSD is a chronic mental health condition that drastically reduces an individual's quality of life Dextrose injection with a small needle has been used for chronic pain patients and observational results have shown it to be effective in reducing anxiety, brain fog, and depression in patients with PTSD. This randomized trial will compare dextrose injection with an injection control of normal saline (NS)
The 2 groups in the trial
- D5W cervical plexus hydrodissectionTreatment being tested
10 ml D5W cervical plexus hydrodissection bilaterally at 0, 2, 4, and 8 weeks, and then by request from 13-52 weeks
Treatment: Dextrose 5% in water bilateral injection
- Normal saline cervical plexus hydrodissectionExisting treatment, for comparison
10 mL normal saline cervical plexus hydrodissection bilaterally at 0, 2, 4, and 8 weeks, and then D5W by request from 13-52 weeks
Treatment: Normal saline bilateral injection
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Fit questions
- Built from NCT07382596, who can take part
- Record updated
- 9 November 2026