Ultrasound-Guided Stellate Ganglion Block Plus Propofol for Perimenopausal Insomnia With Anxiety
Key facts
- Who runs it
- Xiaochen Ji
- Where
- China1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 233 people enrolled
- Started
- 1 May 2022
- Ended
- 31 Jan 2025
- Type of study
- Interventional, 2 groupsOne group gets a sham (pretend) treatment, for comparison.
- Treatments tested
- Ultrasound-Guided Stellate Ganglion Block
- Sham Stellate Ganglion Block
- Record updated
- 3 February 2026
Who can take part
- Age
- 35 years to 55 years
- Sex
- Women only
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 16 criteriaShow less
Who can take part
- Female patients aged 35 to 55 years
- Diagnosed with uterine fibroids and scheduled for elective laparoscopic myomectomy
- American Society of Anesthesiologists (ASA) physical status classification I or II
- Normal cognitive function and ability to understand the study procedures
- Provided written informed consent prior to participation
Who cannot take part
- Preexisting significant sleep disorders prior to surgery
- Conversion to open surgery during the procedure
- Unplanned admission to the intensive care unit after surgery
- Contraindications to stellate ganglion block, including coagulation disorders, infection at the puncture site, or allergy to local anesthetics
- Severe dysfunction of major organs, including heart, liver, or kidney
- Poorly controlled chronic diseases such as hypertension or diabetes mellitus
- History of psychiatric disorders, chronic pain conditions, or long-term use of sedatives, analgesics, or medications affecting autonomic nervous system function
- Abnormal cervical anatomy, history of cervical surgery, or radiotherapy
- Failure of stellate ganglion block
- Occurrence of serious adverse events related to the block procedure, such as nerve injury, arrhythmia, or local anesthetic systemic toxicity
- Anticipated difficult airway
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
Laparoscopic myomectomy is a commonly performed minimally invasive gynecologic procedure. However, surgical trauma, tracheal intubation, and pneumoperitoneum may induce pronounced perioperative stress responses, resulting in hemodynamic instability, postoperative pain, inflammatory activation, sleep disturbance, and anxiety, which can delay postoperative recovery.
Read full original descriptionShow less
Stellate ganglion block (SGB) is a sympathetic nerve modulation technique that has been shown to attenuate stress-related sympathetic overactivity. This study aimed to evaluate the clinical effects and safety of ultrasound-guided right-sided stellate ganglion block combined with standardized general anesthesia in patients undergoing laparoscopic myomectomy.
In this randomized controlled study, a total of 240 patients scheduled for laparoscopic myomectomy were randomly assigned to either a combined block group (ultrasound-guided right-sided SGB before anesthesia induction plus general anesthesia) or a general anesthesia group (sham saline injection plus general anesthesia). Perioperative hemodynamic parameters, heart rate variability, postoperative pain scores, analgesic requirements, recovery profiles, inflammatory stress markers, sleep quality, anxiety levels, and adverse events were compared between groups.
This study was retrospectively registered after completion. The results are intended to provide evidence for optimizing perioperative management and enhancing recovery in patients undergoing laparoscopic myomectomy.
The 2 groups in the trial
- Combined Block GroupTreatment being tested
Patients received ultrasound-guided right-sided stellate ganglion block prior to anesthesia induction, followed by standardized general anesthesia for laparoscopic myomectomy.
Treatment: Ultrasound-Guided Stellate Ganglion Block
- General Anesthesia GroupSham treatment, for comparison
Patients received an ultrasound-guided sham injection with an equal volume of normal saline at the stellate ganglion prior to anesthesia induction, followed by standardized general anesthesia for laparoscopic myomectomy.
Treatment: Sham Stellate Ganglion Block
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Ultrasound-Guided Stellate Ganglion Block Combined With Propofol for Perimenopausal Insomnia With Anxiety
- Record updated
- 3 February 2026