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Enrolling by invitationNo phase

Screening Relatives of Brain Bleed Patients for Unruptured Brain Aneurysms

Checks close relatives of people with brain bleeding for unruptured aneurysms using brain scans.

Key facts

Who runs it
University of Novi Sad
Where
Novi Sad, SerbiaSee the site
Trial code
Registry title
Screening in Relatives With Elevated Risk for Unruptured Intracranial Aneurysms
Status
Enrolling by invitation
People taking part
300 people, planned
Started
1 Feb 2026
Expected to end
31 Jan 2027
Type of study
Observational
Record updated
4 February 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults aged 30 or older who are first-degree relatives of a person with aneurysmal subarachnoid hemorrhage. They must smoke or have high blood pressure. Screening uses magnetic resonance angiography (MRA) to look for unruptured brain aneurysms.

Age
30 years or older at enrollment.
Sex
Men and women can join.
Disease stage
Relatives of patients diagnosed with aneurysmal subarachnoid hemorrhage (aSAH). Relatives with a sporadic aneurysm must have a confirmed unruptured aneurysm.
Earlier treatment
Not stated. A history of aneurysm rupture or earlier subarachnoid hemorrhage means a person cannot join.
Biomarker or test result
Current cigarette smoker, or diagnosed with hypertension (treated or untreated).

Main reasons for not taking part

  • Earlier brain aneurysm rupture or subarachnoid hemorrhage
  • Cannot have an MRI or MRA (for example pacemaker, metal implants, severe claustrophobia) or is pregnant
  • Polycystic kidney disease, Marfan's Syndrome, Ehlers Danlos Syndrome or fibromuscular dysplasia
  • Cannot or does not want to give informed consent
  • Taking part in another interventional study that could interfere with the results

The registry criteria, word for word

Show all 9 criteriaShow less

Who can take part

  • First-degree relatives (parents, siblings, or children) of patients diagnosed with aneurysmal subarachnoid hemorrhage (aSAH)
  • Age ≥ 30 years at the time of enrollment, and current cigarette smokers or diagnosed with hypertension (either treated or untreated)
  • Able and willing to undergo magnetic resonance angiography (MRA)
  • Able to provide written informed consent; 6. Sporadic aneurysm subjects must have a confirmed UIAs

Who cannot take part

  • History of intracranial aneurysm rupture or prior subarachnoid hemorrhage
  • Contraindications to MRI/MRA (e.g., pacemaker, metallic implants, severe claustrophobia) or pregnancy (due to MRI safety considerations)
  • A history of polycystic kidney disease, Marfan's Syndrome, Ehlers Danlos Syndrome, or fibromuscular dysplasia
  • Unable or unwilling to provide informed consent
  • Participation in another interventional study that could interfere with outcomes

Where in Serbia

  • University Clinical Center of VojvodinaNovi Sad, SerbiaNo longer taking part

About the trial

What the trial wants to find out

The purpose of this study is to screen first-degree relatives of patients with aneurysmal subarachnoid hemorrhage using magnetic resonance angiography to detect unruptured intracranial aneurysms. This study aims to identify individuals who are at increased risk and determine the effect of environmental factors for development of unruptured intracranial aneurysms.

The group in the trial

  • Study Group

    150 individuals that are first-degree relatives of affected patients admitted to study center for aneurysmal stroke and 150 individuals with sporadic UIAs

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

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Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Screening for Intracranial Unruptured Aneurysms in First-Degree Relatives of Patients With Aneurysmal Subarachnoid Hemorrhage
Plain-language title
Screening Relatives of Brain Bleed Patients for Unruptured Brain AneurysmsGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
4 February 2026