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Two Ways of Stimulating the Ovaries During IVF in Women With PCOS

Compares two ovarian stimulation methods for IVF in women with polycystic ovary syndrome.

Plain-language title generated from the registry record
Registry title: Comparison of IVF Outcomes Between PPOS and Antagonist Protocols in Women With PCOS

Key facts

Where
Hanoi, VietnamSee the site

AI summary: who the study is looking for

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for women with polycystic ovary syndrome (PCOS) who need in vitro fertilization (IVF). It compares two ways of stimulating the ovaries.

Age
18 to 40 years
Sex
Women only
Disease stage
PCOS diagnosed by the modified Rotterdam criteria (2004), meaning at least 2 of 3 signs: irregular or no ovulation, high male hormone levels, or polycystic ovaries on ultrasound. IVF must be needed because of PCOS alone or PCOS with other causes, such as blocked tubes or a failed IUI.
Earlier treatment
No major ovarian or uterine surgery that affects ovarian reserve or the uterus (for example ovarian cystectomy, endometriosis surgery, myomectomy, removal of one ovary).
Biomarker or test result
The partner must have normal sperm, or mild to moderate oligoasthenoteratozoospermia (OAT, low sperm number, movement and shape).

Main reasons for not taking part

  • Uterine abnormalities that may affect implantation or pregnancy
  • Major ovarian or uterine surgery in the past
  • 3 or more spontaneous miscarriages
  • Known chromosomal abnormalities in either partner
  • Cannot follow the study procedures or follow-up

Read by machine on 13 November 2026.

Could this be for you?

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 40 years old?

Source: NCT07394530, who can take part

Where in Vietnam

  • Hanoi General HospitalHanoi, VietnamContact: Phuong Duy Nguyen, MD, MSTaking people

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Trial details

Who runs it
Hanoi General Hospital (Vietnam)
Trial code
NCT07394530
Record updated
5 August 2026
Original description
This study aims to compare the outcomes of two ovarian stimulation protocols used in in vitro fertilization (IVF): the progestin-primed ovarian stimulation (PPOS) protocol and the GnRH antagonist protocol.Read full original descriptionShow less

A Comparative Study of In Vitro Fertilization Outcomes Between PPOS and Antagonist Protocols in Women With Polycystic Ovary Syndrome

This study aims to compare the outcomes of two ovarian stimulation protocols used in in vitro fertilization (IVF): the progestin-primed ovarian stimulation (PPOS) protocol and the GnRH antagonist protocol.

Inclusion: Women aged 18-40 years; Diagnosed with polycystic ovary syndrome (PCOS) according to the modified Rotterdam criteria (2004) (≥2 of 3: oligo/anovulation, hyperandrogenism, or polycystic ovarian morphology on ultrasound); Indicated for in vitro fertilization (IVF) due to PCOS alone or PCOS with other infertility factors (e.g., tubal factor, previous failed IUI); Eligible for controlled ovarian stimulation for IVF; Husband/partner with normal sperm parameters or mild to moderate oligoasthenoteratozoospermia (OAT); Willing and able to provide written informed consent and comply with study procedures.

Exclusion: History of major ovarian or uterine surgery affecting ovarian reserve or uterine structure (e.g., ovarian cystectomy, endometriosis surgery, myomectomy, unilateral oophorectomy); History of recurrent pregnancy loss (≥3 spontaneous miscarriages); Uterine abnormalities that may impair implantation or pregnancy outcomes, including congenital uterine malformations, large fibroids distorting the uterine cavity, adenomyosis, or severe intrauterine pathology; Known chromosomal abnormalities in either partner; Inability to adhere to study protocol or follow-up procedures.

ClinicalTrials.gov NCT07394530