Repeated brain stimulation with mild electric current for movement problems in Parkinson's disease
Tests repeated mild electrical brain stimulation on movement in people with Parkinson's disease.
Plain-language title generated from the registry record
Registry title: Effect of Repetitive Bihemispheric Anodal Transcranial Direct Current Stimulation on Motor Function of Patients With Parkinson's Disease
Key facts
- Where
- New Delhi, IndiaSee the site
- Phase
- Phase 3
Where in India
- Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia HospitalNew Delhi, IndiaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Dr. Ram Manohar Lohia Hospital
- Trial code
- NCT07395531
- Record updated
- 9 February 2026
- Original description
Dopaminergic medications and Deep Brain Stimulation (DBS) are the current standards interventions for Parkinson's Disease. Pharmacotherapy with dopaminergic drugs leads to partial improvement in motor functions of patients. Invasive therapies like DBS have as yet limited availability and accessibility, with risk of adverse events as well. Non invasive therapies like Transcranial Direct Current Stimulation (tDCS) are currently increasingly being probed for their therapeutic value, in view of their safety, portability and convenience of administration.Read full original descriptionShow less
Effect of Repetitive Bihemispheric Anodal Transcranial Direct Current Stimulation on Motor Function of Patients With Parkinson's Disease
Dopaminergic medications and Deep Brain Stimulation (DBS) are the current standards interventions for Parkinson's Disease. Pharmacotherapy with dopaminergic drugs leads to partial improvement in motor functions of patients. Invasive therapies like DBS have as yet limited availability and accessibility, with risk of adverse events as well. Non invasive therapies like Transcranial Direct Current Stimulation (tDCS) are currently increasingly being probed for their therapeutic value, in view of their safety, portability and convenience of administration.
Improvement in motor function immediately after a single session of tDCS has been observed. The effect of single simulation is not sustained beyond a few days. Only few studies with varied sites of stimulation have evaluated the effect of repetitive tDCS on motor function improvement in patients with Parkinson's Disease, with conflicting results. There is an unmet need to probe the utility of repetitive tDCS on motor function of patients with Parkinson's Disease.
We aim to probe the effect of repetitive tDCS of dorsolateral prefrontal cortex and M1 cortex on motor function in patients with Parkinson's Disease (Hoehn and Yahr stage 2 to 4).
Inclusion: Patients fulfilling the Movement Disorder Society (MDS) clinical diagnostic criteria for Parkinson's disease; Patients with Hoehn \& Yahr stages 2-4 Parkinson's disease; Patients maintained on stable medical regimen for at least 1 month before entering the study.
Exclusion: Patients with skull defect due to surgery e.g. craniectomy; Patients with other confounding neurological and psychiatric disorders; Patients with a history of deep brain stimulation; Patients with history of seizures; Patients with scalp condition likely to obstruct application of electrodes; The presence of metal objects or stimulators in the head.