A Ketogenic Supplement Taken in the Evening by Older Adults With Overweight
Tests an evening ketogenic supplement for 4 weeks in older adults with overweight.
Plain-language title generated from the registry record
Registry title: The Effects of a 4-week Supplementation With a Ketogenic Nutrient Mix on 24-hour Substrate Metabolism and Muscle Health
Key facts
- Where
- Maastricht, NetherlandsSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 60 and 80 years old?
Source: NCT07395973, who can take part
Where in Netherlands
- Maastricht UniversityMaastricht, NetherlandsTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Maastricht University Medical Center
- Trial code
- NCT07395973
- Record updated
- 9 February 2026
- Original description
This study will investigate the effect of providing a daily ketogenic nutritional supplement in the evening for a prolonged time (4 weeks) to induce a mild ketogenic state during the night in healthy elderly (60-80 years), overweight/obese (BMI: 25-35 kg/m2) individuals with low physical activity, on 24h rhythmicity in energy metabolism as compared to a non-ketogenic, isocaloric control.Read full original descriptionShow less
The Effects of a 4-week Supplementation With a Ketogenic Nutrient Mix on 24-hour Substrate Metabolism and Muscle Health
This study will investigate the effect of providing a daily ketogenic nutritional supplement in the evening for a prolonged time (4 weeks) to induce a mild ketogenic state during the night in healthy elderly (60-80 years), overweight/obese (BMI: 25-35 kg/m2) individuals with low physical activity, on 24h rhythmicity in energy metabolism as compared to a non-ketogenic, isocaloric control.
Inclusion: Aged 60-80 years; Body mass index (BMI) 25-35 kg/m2; Sedentary lifestyle (not more than 2 hours of structured physical activity per week in the past 3 months); Stable dietary habits (no weight loss or gain > 5 kg in the past 3 months); Healthy (as determined by dependent physician based on medical questionnaire); Regular sleeping habits (7-9h of daily sleep).
Exclusion: Previous enrolment in a clinical study with an investigational product during the last 3 months or as judged by the investigator which would possibly hamper our study results; Blood donation during or within 2 months prior to the study; Type 2 diabetes; Participants with active congestive heart failure and/or severe renal and or liver insufficiency; Uncontrolled hypertension; Significant food allergies/intolerance (seriously hampering study meals or study product); Alcohol consumption of >3 servings per day for men and >2 servings per day for women; Unstable body weight (weight gain or loss > 5 kg in the last 3 months) or intention to lose weight; Participants who are on an intermittent fasting diet; Participants who do not want to be informed about unexpected medical findings; Disturbances in circadian rhythm determined with the follow criteria:; Extreme early bird or extreme night person (score ≤30 or ≥70 on MEQ-SA questionnaire); Heavily varying sleep-wake rhythm; Night shift work during last 3 months; Travel across > 1 time zone in the last 3 months; High daily caffeine intake > 400mg (more than 4 cups of coffee or energy drinks).