Surgery and brain imaging for blocked neck arteries that supply the brain
Studies surgical bypass and scans in adults with long-term carotid artery blockage.
Plain-language title generated from the registry record
Registry title: Effectiveness of Surgical and Diagnostic Methods in Cerebral Vascular Occlusive Disease
Key facts
- Where
- Astana, KazakhstanSee the site
Where in Kazakhstan
- National Centre for NeurosurgeryAstana, KazakhstanNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- National Centre for Neurosurgery, Republic of Kazakhstan
- Trial code
- NCT07396025
- Record updated
- 9 February 2026
- Original description
This study attempts to improve surgical treatment outcomes among people with chronic carotid artery occlusive disease by conducting a comprehensive review of neuroradiological, clinical, and cognitive data. The evaluation involves an extensive angiographic analysis, including pre- and postoperative measurements of superficial temporal artery branch diameters, assessment of the Circle of Willis and collateral pathways, alongside cerebral perfusion metrics, cognitive status, and clinical outcomes. Major focus is directed towards evaluating the degree of intracranial revascularization following to extracranial-intracranial bypass by postoperative angiographic evaluations. This integrative strategy aims to refine surgical reasons, better predictions of functional and cognitive outcomes, minimize postoperative risks, and eventually improve the overall efficacy of treatment in this patient population.Read full original descriptionShow less
Evaluation of the Effectiveness of Surgical and Diagnostic Techniques in Patients With Steno-occlusive Diseases of the Cerebral Vessels
This study attempts to improve surgical treatment outcomes among people with chronic carotid artery occlusive disease by conducting a comprehensive review of neuroradiological, clinical, and cognitive data. The evaluation involves an extensive angiographic analysis, including pre- and postoperative measurements of superficial temporal artery branch diameters, assessment of the Circle of Willis and collateral pathways, alongside cerebral perfusion metrics, cognitive status, and clinical outcomes. Major focus is directed towards evaluating the degree of intracranial revascularization following to extracranial-intracranial bypass by postoperative angiographic evaluations. This integrative strategy aims to refine surgical reasons, better predictions of functional and cognitive outcomes, minimize postoperative risks, and eventually improve the overall efficacy of treatment in this patient population.
Inclusion: Patients with ICA occlusion confirmed by CTA, MRA, and cerebral DSA; MRI ASL-confirmed hypoperfusion in the territory of the occluded ICA (decrease of ≥30% compared with the contralateral side); Language comprehension is preserved, with mild or no motor aphasia and no significant cognitive impairment; Patients aged from 18 to 80 years; Modified Rankin Scale (mRS) score 0-2; Informed consent is available from the patient or legal guardian; Accessible and reliable patients for follow-up.
Exclusion: Contraindications to MRI, CTA, DSA, iodinated contrast agents, or antiplatelet therapy required in the perioperative period; Participation in another interventional or experimental trial within the previous 12 months, including studies involving ionizing radiation; -; Patients with severe somatic conditions or mRS score > 3; Patients with bilateral ICA occlusion, neurovascular disease (cerebral aneurysm or arteriovenous malformation); Cardiac conditions associated with a high risk of cerebral embolism, including prosthetic heart valves, infective endocarditis, intracardiac thrombus, sick sinus syndrome, cardiac myxoma, or cardiomyopathy with left ventricular ejection fraction <25% (atrial fibrillation, patent foramen ovale, and atrial septal aneurysm are not exclusion criteria); Patients aged under 18; Severe systemic comorbidities, life expectancy <2 years, or a modified Rankin Scale (mRS) score >3; Patients with large territorial infarction or marked cerebral atrophy on MRI; No evidence of regional hypoperfusion on ASL MRI relative to the contralateral hemisphere; Patients with a non-functioning STA-MCA bypass; Patients with Contraindications to MRI, CTA, or DSA; Pregnancy.