Measuring SCUBE Proteins in Women With Polycystic Ovary Syndrome
Measures SCUBE-1 and SCUBE-3 blood proteins in women with polycystic ovary syndrome.
Plain-language title generated from the registry record
Registry title: SCUBE Proteins in Polycystic Ovary Syndrome (IPSOS)
Key facts
- Where
- Roma, ItalySee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for women aged 18-35 with polycystic ovary syndrome (PCOS), and healthy women as a comparison group.
- Age
- 18-35 years
- Sex
- Women only
- Disease stage
- Polycystic ovary syndrome, with normal or high insulin levels. Healthy women can join as the control group.
- Biomarker or test result
- Basal hormone tests and an oral glucose tolerance test must be available.
Main reasons for not taking part
- Pregnancy
- Heart or blood vessel disease in the past
- Diabetes or impaired glucose tolerance
- High blood pressure
- Obesity
Read by machine on 13 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 35 years old?
Source: NCT07396402, who can take part
Where in Italy
- Fondazione Policlinico Universitario Agostino Gemelli IRCCSRoma, ItalyContact: Rosanna Apa, MD, PhDNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Trial code
- NCT07396402
- Record updated
- 9 February 2026
- Original description
This study investigates circulating levels of SCUBE-1 and SCUBE-3 proteins in women with polycystic ovary syndrome (PCOS) compared with healthy controls. Differences between normoinsulinemic and hyperinsulinemic PCOS subgroups will be evaluated, as well as correlations with clinical and metabolic parameters related to inflammation and cardiovascular risk.Read full original descriptionShow less
Study of Scube-1 and Scube-3 in Polycystic Ovary Syndrome (PCOS) and Their Possible Use as Inflammatory Markers and as a Link Between PCOS and Cardiovascular Events.
This study investigates circulating levels of SCUBE-1 and SCUBE-3 proteins in women with polycystic ovary syndrome (PCOS) compared with healthy controls. Differences between normoinsulinemic and hyperinsulinemic PCOS subgroups will be evaluated, as well as correlations with clinical and metabolic parameters related to inflammation and cardiovascular risk.
Inclusion: Female subjects aged 18-35 years; Diagnosis of polycystic ovary syndrome (normoinsulinemic or hyperinsulinemic); Availability of basal hormonal evaluation and oral glucose tolerance test; Healthy women for control group; Written informed consent.
Exclusion: History of cardiovascular disease; Hypertension; Significant hepatic or renal disease; Other endocrine disorders; Neoplastic diseases; Psychiatric disorders; Autoimmune diseases; Diabetes mellitus or impaired glucose tolerance; Pregnancy; Shift work; Obesity; Refusal to sign informed consent.