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Taking people in United StatesPhase 3

Fibromyalgia Response With Esreboxetine Evaluated Using a Randomized Withdrawal Research Design

Key facts

Where
Anaheim, Atlanta, Austin, Boston, Brooklyn, Charleston, Chicago, Cranston, Cromwell, Dallas, Duncansville, Glendale, Hartsdale, Hazelwood, High Point, Hollywood, Houston, Huber Heights, Jacksonville, Kansas City, Knoxville, Lakeland, Las Vegas, Little Rock, Louisville, Maitland, Marietta, Memphis, Milford, Norcross, North Dartmouth, Oceanside, Orlando, Overland Park, Phoenix, Plymouth Meeting, Prairieville, Prosper, Redlands, Rockville, Sacramento, San Antonio, Santa Ana, Springfield, Tampa, The Villages, The Woodlands, Tinley Park, Town and Country, Tucson, Tulsa, Watertown, and Williamsville, United StatesSee the 53 sites
Phase
Phase 3

Where in United States

  • Anaheim, CaliforniaHospital not named in the registryContact: Study DirectorTaking people
  • Atlanta, GeorgiaHospital not named in the registryContact: Study DirectorTaking people
  • Austin, TexasHospital not named in the registryContact: Study DirectorTaking people
  • Boston, MassachusettsHospital not named in the registryContact: Study DirectorTaking people
  • Brooklyn, New YorkHospital not named in the registryContact: Study DirectorTaking people
  • Charleston, South CarolinaHospital not named in the registryContact: Study DirectorTaking people
  • Chicago, IllinoisHospital not named in the registryContact: Study DirectorTaking people
  • Cranston, Rhode IslandHospital not named in the registryContact: Study DirectorTaking people
  • Cromwell, ConnecticutHospital not named in the registryContact: Study DirectorTaking people
  • Dallas, TexasHospital not named in the registryContact: Study DirectorTaking people
  • Duncansville, PennsylvaniaHospital not named in the registryContact: Study DirectorTaking people
  • Glendale, CaliforniaHospital not named in the registryContact: Study DirectorTaking people
  • Hartsdale, New YorkHospital not named in the registryContact: Study DirectorTaking people
  • Hazelwood, MissouriHospital not named in the registryContact: Study DirectorTaking people
  • High Point, North CarolinaHospital not named in the registryContact: Study DirectorTaking people
  • Hollywood, FloridaHospital not named in the registryContact: Study DirectorTaking people
  • Houston, TexasHospital not named in the registryContact: Study DirectorTaking people
  • Huber Heights, OhioHospital not named in the registryContact: Study DirectorTaking people
  • Jacksonville, FloridaHospital not named in the registryContact: Study DirectorTaking people
  • Kansas City, KansasHospital not named in the registryContact: Study DirectorTaking people
  • Knoxville, TennesseeHospital not named in the registryContact: Study DirectorTaking people
  • Lakeland, FloridaHospital not named in the registryContact: Study DirectorTaking people
  • Las Vegas, NevadaHospital not named in the registryContact: Study DirectorTaking people
  • Little Rock, ArkansasHospital not named in the registryContact: Study DirectorTaking people
  • Louisville, KentuckyHospital not named in the registryContact: Study DirectorTaking people
  • Maitland, FloridaHospital not named in the registryContact: Study DirectorTaking people
  • Marietta, GeorgiaHospital not named in the registryContact: Study DirectorTaking people
  • Memphis, TennesseeHospital not named in the registryContact: Study DirectorTaking people
  • Milford, OhioHospital not named in the registryContact: Study DirectorTaking people
  • Norcross, GeorgiaHospital not named in the registryContact: Study DirectorTaking people
  • North Dartmouth, MassachusettsHospital not named in the registryContact: Study DirectorTaking people
  • Oceanside, CaliforniaHospital not named in the registryContact: Study DirectorTaking people
  • Orlando, FloridaHospital not named in the registryContact: Study DirectorTaking people
  • Overland Park, KansasHospital not named in the registryContact: Study DirectorTaking people
  • Phoenix, ArizonaHospital not named in the registryContact: Study DirectorTaking people
  • Plymouth Meeting, PennsylvaniaHospital not named in the registryContact: Study DirectorTaking people
  • Prairieville, LouisianaHospital not named in the registryContact: Study DirectorTaking people
  • Prosper, TexasHospital not named in the registryContact: Study DirectorTaking people
  • Redlands, CaliforniaHospital not named in the registryContact: Study DirectorTaking people
  • Rockville, MarylandHospital not named in the registryContact: Study DirectorTaking people
  • Sacramento, CaliforniaHospital not named in the registryContact: Study DirectorTaking people
  • San Antonio, TexasHospital not named in the registryContact: Study DirectorTaking people
  • Santa Ana, CaliforniaHospital not named in the registryContact: Study DirectorTaking people
  • Springfield, MassachusettsHospital not named in the registryContact: Study DirectorTaking people
  • Tampa, FloridaHospital not named in the registryContact: Study DirectorTaking people
  • The Villages, FloridaHospital not named in the registryContact: Study DirectorTaking people
  • The Woodlands, TexasHospital not named in the registryContact: Study DirectorTaking people
  • Tinley Park, IllinoisHospital not named in the registryContact: Study DirectorTaking people
  • Town and Country, MissouriHospital not named in the registryContact: Study DirectorTaking people
  • Tucson, ArizonaHospital not named in the registryContact: Study DirectorTaking people
  • Tulsa, OklahomaHospital not named in the registryContact: Study DirectorTaking people
  • Watertown, MassachusettsHospital not named in the registryContact: Study DirectorTaking people
  • Williamsville, New YorkHospital not named in the registryContact: Study DirectorTaking people

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Trial details

Who runs it
Axsome Therapeutics, Inc.
Trial code
NCT07398417
Record updated
10 November 2026
Original description
The study is a Phase 3, double-blind, placebo-controlled, randomized withdrawal study to assess the efficacy and safety of AXS-14 in the management of fibromyalgia.Read full original descriptionShow less

A Double-Blind, Placebo-Controlled, Randomized Withdrawal Study to Assess the Efficacy and Safety of AXS-14 in the Management of Fibromyalgia

The study is a Phase 3, double-blind, placebo-controlled, randomized withdrawal study to assess the efficacy and safety of AXS-14 in the management of fibromyalgia.

Inclusion: Has a primary diagnosis of fibromyalgia based on the 2016 ACR diagnostic criteria; Male or female, ≥18 years of age; Provides written informed consent to participate in the study before conducting any study procedures.

Exclusion: Previous participation in a clinical trial with reboxetine or esreboxetine or currently receiving treatment with reboxetine for any condition; Unable to comply with study procedures; Medically inappropriate for study participation in the opinion of the investigator.

ClinicalTrials.gov NCT07398417