Effectiveness of Micro-needling With 5 Fluorouracil Versus Potent Topical Steroids in the Treatment of Limited Vitiligo
Key facts
- Phase
- Early phase 1
This trial has no sites in United States.
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Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 4 and 70 years old?
Source: NCT07398807, who can take part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Combined Military Hospital (CMH) institute of Medical Sciences Bahawalpur Pakistan
- Trial code
- NCT07398807
- Record updated
- 17 February 2026
- Original description
The goal of this clinical trial is to learn how well 5 fluorouracil (5FU) with micro-needling works to treat limited vitiligo as compared to strong steroid applied on skin. It will also learn about the safety of both these treatments. The main questions it aims to answer are:Read full original descriptionShow less
Effectiveness of Combining Micro Needling With 5 Fluorouracil Versus Potent Topical Steroids; in Treating Limited Vitiligo- Randomised Controlled Study
The goal of this clinical trial is to learn how well 5 fluorouracil (5FU) with micro-needling works to treat limited vitiligo as compared to strong steroid applied on skin. It will also learn about the safety of both these treatments. The main questions it aims to answer are:
* How well does 5FU with microneedling work to treat vitiligo by returning pigmentation in vitiligo patches as compared to steroid? * What is participant's satisfaction when treated with 5FU with microneedling as compared to steroid? * What skin problems do participants have when treated with FU with microneedling and steroid?
Researchers will compare 5FU with microneedling to steroid application to see how well both work to return pigment in vitiligo patches.
Participants will be divided into two groups. For Group A, 5 FU will be rubbed and absorbed on the vitiligo patch after micro-needling every 2 weeks.
For group B, topical 0.05% clobetasol propionate ointment will be applied twice a day on the vitiligo patches for 12 weeks.
Vitiligo patches will be assessed at the start of trial and then after 12 weeks of treatment.
Inclusion: Patients willing to participate in the study; Patients of age group of 05 -70 years; Vitiligo involving less than or equal to 10% body surface area.
Exclusion: Patients on immunosuppressant medications due to other diseases; Patient having history of keloids or hypertrophic scars; Patients with history of hypersensitivity to either of the drugs; Patients having anemia, immunosuppression, bleeding disorder, taking anticoagulants or anti-platelet drugs or having epilepsy; Patients using or have used other treatments for vitiligo; Pregnant women or lactating women; Patients with unstable vitiligo.