Exercise heart MRI to help diagnose heart failure with preserved ejection fraction
Tests exercise heart MRI as a diagnostic tool in adults with breathlessness on exertion.
Plain-language title generated from the registry record
Registry title: Exercise Cardiovascular Magnetic Resonance In Heart Failure With Preserved Ejection Fraction
Key facts
- Where
- Rochester, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT07401771, who can take part
Where in United States
- Mayo Clinic in RochesterRochester, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Mayo Clinic
- Trial code
- NCT07401771
- Record updated
- 20 August 2026
- Original description
The purpose of this study is to internally validate low-field Ex-CMR as a noninvasive tool for diagnosing, phenotyping, and risk stratifying HFpEF in patients with exertional dyspnea.Read full original descriptionShow less
Exercise Cardiovascular Magnetic Resonance In Heart Failure With Preserved Ejection Fraction
The purpose of this study is to internally validate low-field Ex-CMR as a noninvasive tool for diagnosing, phenotyping, and risk stratifying HFpEF in patients with exertional dyspnea.
Inclusion: Informed consent obtained; Three groups will be enrolled:; HFpEF (cardiologist-adjudicated diagnosis as verified by PI, EF≥50%); Non-cardiac dyspnea (patients have dyspnea but were found on invasive exercise testing not to have HFpEF); Healthy volunteers with no history of dyspnea or effort intolerance.
Exclusion: Cardiac implants, mechanical or biological valve, causing artifacts that compromise the quality of data; Hospitalization for heart failure in the preceding 30 days; Myocardial infarction or unstable angina pectoris; Other causes of dyspnea as indicated in patients' medical history based upon the opinion of the PI, such as restrictive cardiomyopathy or infiltrative conditions (e.g., amyloidosis), hypertrophic obstructive cardiomyopathy, primary pulmonary arterial hypertension, more than moderate chronic obstructive pulmonary disease, right heart failure due to pulmonary disease, complex congenital heart disease, severe anemia, or more than moderate mitral or aortic heart valve disease); Contraindication for low-field CMR, as indicated in MRI safety screening checklist (Research Document #1); Patient inability or unwillingness to undergo Ex-CMR; Large R-R interval variation, caused by frequent premature ventricular contractions or non-sinus rhythms such as persistent atrial fibrillation, which, in the opinion of the investigators, compromises the quality of data acquisition, image analysis and disrupts the consistency of the cohorts; Planned coronary, carotid, or peripheral artery revascularization.