How electrochemotherapy changes the tissue around melanoma spread in the skin
Studies tissue changes after electrochemotherapy in adults with melanoma that has spread to skin.
Plain-language title generated from the registry record
Registry title: Electrochemotherapy-Induced Changes in Tumor Microenvironment in Cutaneous Melanoma
Key facts
- Where
- Ljubljana, SloveniaSee the site
Where in Slovenia
- Institute of Oncology LjubljanaLjubljana, SloveniaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Institute of Oncology Ljubljana
- Trial code
- NCT07404605
- Record updated
- 19 February 2026
- Original description
Cutaneous melanoma frequently develops cutaneous and subcutaneous metastases, which may cause significant morbidity and negatively affect quality of life. Electrochemotherapy (ECT) is an established local treatment modality for cutaneous and subcutaneous tumor lesions that combines the administration of cytotoxic drugs with the application of electric pulses to increase drug uptake into tumor cells.Read full original descriptionShow less
Electrochemotherapy Induces Changes in Tumor Microenvironment of Cutaneous and Subcutaneous Metastases in Patients With Cutaneous Melanoma
Cutaneous melanoma frequently develops cutaneous and subcutaneous metastases, which may cause significant morbidity and negatively affect quality of life. Electrochemotherapy (ECT) is an established local treatment modality for cutaneous and subcutaneous tumor lesions that combines the administration of cytotoxic drugs with the application of electric pulses to increase drug uptake into tumor cells.
In addition to its direct cytotoxic effects, electrochemotherapy may induce changes in the tumor microenvironment, including immune cell infiltration, vascular alterations, and other biological responses that could influence tumor control.
The aim of this study is to evaluate changes in the tumor microenvironment of cutaneous and subcutaneous melanoma metastases following electrochemotherapy with either intravenous bleomycin or intratumoral cisplatin. Tumor tissue samples collected before and after treatment will be analyzed to characterize microenvironmental changes and to compare treated and untreated lesions.
The results of this study may improve understanding of biological effects of electrochemotherapy in melanoma metastases and support further development of treatment strategies.
Inclusion: Adults aged 18 years or older; Histologically confirmed cutaneous melanoma; Presence of cutaneous and/or subcutaneous metastases eligible for electrochemotherapy; Candidate for electrochemotherapy with intravenous bleomycin or intratumoral cisplatin according to standard clinical practice; Ability to provide written informed consent.
Exclusion: Contraindication to electrochemotherapy or study drugs (bleomycin or cisplatin); Pregnancy or breastfeeding; Severe comorbidities preventing electrochemotherapy; Inability to comply with study procedures.