Ear Nerve Stimulation Tested Alongside Standard Care After Ischemic Stroke
Tests ear-based vagus nerve stimulation added to usual care in adults with acute ischemic stroke.
Plain-language title generated from the registry record
Registry title: Non-invasive Vagus Nerve Stimulation to Reduce Inflammation and Brain Injury Blood Biomarkers Following an Acute Ischemic Stroke
Key facts
- Where
- St Louis, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 99 years old?
Source: NCT07404852, who can take part
Where in United States
- Barnes-Jewish HospitalSt Louis, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Washington University School of Medicine
- Trial code
- NCT07404852
- Record updated
- 13 April 2026
- Original description
This is a randomized open-label, with blinded outcome pilot study to evaluate the effect on inflammatory and brain injury laboratory values and explore clinical outcomes in patients who present with ischemic strokes due to large vessel occlusions and are treated with either current accepted management, or accepted management in addition to transcutaneous auricular vagal nerve stimulation.Read full original descriptionShow less
Neuromodulation Using Vagus Nerve Stimulation Following Ischemic Stroke as Therapeutic Adjunct 2
This is a randomized open-label, with blinded outcome pilot study to evaluate the effect on inflammatory and brain injury laboratory values and explore clinical outcomes in patients who present with ischemic strokes due to large vessel occlusions and are treated with either current accepted management, or accepted management in addition to transcutaneous auricular vagal nerve stimulation.
Inclusion: Adult patients who present with acute ischemic strokes due to large vessel occlusions.
Exclusion: Chronic or acute infection, Recent surgery, active immune disease; patients' undergoing active cancer or immunosuppressive/modulating therapy; patients with sustained bradycardia on arrival with a heart rate <50 beats per minute; <18 years old; patients with presumed chronic large vessel occlusions; NIHSS<6; pre-morbid modified Rankin score (mRS) >2; unable to initiate treatment under 24 hours from symptom discovery; life expectancy <3 months.