Entropy-based Physiological Signal Analysis in Patients With Obstructive Sleep Apnoea
Key facts
- Who runs it
- King's College London
- Where
- United Kingdom2 sites in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 56 people enrolled
- Started
- 11 Jun 2026
- Ended
- 3 Sept 2026
- Type of study
- Observational
- Treatments tested
- Continuous Positive Airway Pressure Therapy
- Record updated
- 30 October 2026
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
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Who can take part
- Participation in the 3DPiPPIn trial
- Availability of physiological signal data at baseline and at least one follow-up time point (i.e. three months and/or six months post-CPAP)
- Provision of informed consent permitting the use of their data in future research
Who cannot take part
- Non-participation in the 3DPiPPIn trial
- Absence of physiological signal data at both follow-up time points (i.e. no available data at either three months or six months post-CPAP)
- No consent for the use of their data in future research
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
This observational study is being undertaken as a part of a Master of Research (MRes) in Clinical Research programme.
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Its goal is to learn about how continuous positive airway pressure (CPAP) therapy changes the complexity of body signals in adults with obstructive sleep apnoea (OSA). The main question it aims to answer is:
- How does the complexity of physiological signals (specifically oxygen saturation, heart rate, and heart rate variability) change in adults with OSA from before to after three and six months of CPAP treatment?
It will use data from individuals who took part in an earlier trial, called 3DPiPPIn, which tested the use of 3D-printed, customised masks CPAP masks through sleep studies.
The group in the trial
- 3DPiPPIn Trial Participants
Participants were originally recruited to the 3DPiPPIn trial from the Sleep and Ventilation Service at Royal Free London NHS Foundation Trust. The cohort for this secondary analysis comprises adults with sleep-disordered breathing and an Apnoea-Hypopnoea Index (AHI) \>15 events/hour who required but had never received PAP therapy, drawn from the trial participants who provided consent for their data to be used in future research.
Treatment: Continuous Positive Airway Pressure Therapy
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Entropy-Based Assessment of Physiological Signals in Obstructive Sleep Apnoea Patients Pre and Post Continuous Positive Airway Pressure Therapy: A Secondary Analysis of 3DPiPPIn Trial Data
- Record updated
- 30 October 2026