Comparing Two Laser Treatments to Lower Eye Pressure in Open-Angle Glaucoma
Compares direct and standard laser treatment for eye pressure in glaucoma.
Plain-language title generated from the registry record
Registry title: Direct vs Standard SLT for Glaucoma: A Noninferiority Trial
Key facts
- Where
- Charleston, United StatesSee the site
Where in United States
- MUSCCharleston, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Medical University of South Carolina
- Trial code
- NCT07408154
- Record updated
- 6 May 2026
- Original description
This study compares two FDA-approved laser treatments for glaucoma: Direct Selective Laser Trabeculoplasty (DSLT) and Selective Laser Trabeculoplasty (SLT). Both procedures aim to lower eye pressure and prevent vision loss. DSLT is a newer, non-contact technique that may improve comfort and efficiency. Participants will be randomly assigned to receive either DSLT or SLT and followed for 12 months to assess eye pressure, safety, and treatment outcomes.Read full original descriptionShow less
A Randomized Controlled Trial Comparing Direct Selective Laser Trabeculoplasty (DSLT) and Selective Laser Trabeculoplasty (SLT) in Reducing Intraocular Pressure in Open-Angle Glaucoma
This study compares two FDA-approved laser treatments for glaucoma: Direct Selective Laser Trabeculoplasty (DSLT) and Selective Laser Trabeculoplasty (SLT). Both procedures aim to lower eye pressure and prevent vision loss. DSLT is a newer, non-contact technique that may improve comfort and efficiency. Participants will be randomly assigned to receive either DSLT or SLT and followed for 12 months to assess eye pressure, safety, and treatment outcomes.
Inclusion: Age ≥18 years; Diagnosis of OAG (including exfoliative or pigmentary) or OHT; Gonioscopically open angle (visible scleral spur 360°); Ability to consent and comply with follow-up.
Exclusion: IOP >35 mmHg despite therapy; Recent ocular surgery (<6 months); Contraindications to study medications or procedures; Cognitive impairment preventing consent; Angle-closure or secondary glaucomas; Corneal pathology interfering with laser or IOP measurement.