Studies airway germs in very premature babies and later lung health
Follows premature babies born before 32 weeks for lung health and airway germs.
Plain-language title generated from the registry record
Registry title: PremaBiom: Metatranscriptomics of the Respiratory Microbiome to Predict the Occurrence of Bronchopulmonary Dysplasia in Preterm Infants
Key facts
- Where
- Amiens, Caen, Cherbourg, Le Havre, Lille, and Rouen, FranceSee the 6 sites
Where in France
- Service de néonatalogie, CHU d'AmiensAmiens, FranceNo longer taking part
- Service de néonatalogie, CHU de CaenCaen, FranceNo longer taking part
- Service de néonatalogie, CH Cherbourg-en-CotentinCherbourg, FranceNo longer taking part
- Service de néonatalogie, GHT du HavreLe Havre, FranceNo longer taking part
- Service de néonatalogie, CHRU de LilleLille, FranceNo longer taking part
- Service de néonatalogie, CHU de RouenRouen, FranceNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital, Caen
- Trial code
- NCT07411261
- Record updated
- 13 February 2026
- Original description
The goal of this clinical trial is to understand the impact of respiratory microbiome maturation in respiratory health of preterm infants under 32 gestational weeks. The main questions it aims to answer are:Read full original descriptionShow less
PremaBiom: Metatranscriptomics of the Respiratory Microbiome to Predict the Occurrence of Bronchopulmonary Dysplasia in Preterm Infants
The goal of this clinical trial is to understand the impact of respiratory microbiome maturation in respiratory health of preterm infants under 32 gestational weeks. The main questions it aims to answer are:
* What is the role of microbiome maturation in respiratory health (development of bronchopulmonary dysplasia, childhood asthma and viral respiratory infections) of preterm infants ? * Which environmental or health factors are involved in the maturation of the respiratory microbiome ?
Participants will undergo follow-up from birth until 3 years of corrected age including nasal swabs, stool samples, and for some of them blood and milk sample.
Inclusion: Preterm infants with gestational age at birth lower than 32 gestational weeks and 6 days; Hospital stay in one of the participant neonatal care units; Infants covered by the social security system of at least one of their parents; Whose parents have been informed about the study and agree to sign the informed consent form.
Exclusion: Palliative care only; Lack of parental consent; Parents who are minors or under legal protection (guardianship, conservatorship, judicial protection); Parents who do not speak French.