Breathing Muscle Training for People With Amyotrophic Lateral Sclerosis
Tests breathing muscle training devices against sham training in adults with ALS.
Plain-language title generated from the registry record
Registry title: Inspiratory Muscle Training in Amiotrophyc Lateral Sclerosis
Key facts
- Where
- Donostia / San Sebastian, SpainSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 85 years old?
Source: NCT07413718, who can take part
Where in Spain
- ADELA GipuzkoaDonostia / San Sebastian, SpainTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Ramon Llull
- Trial code
- NCT07413718
- Record updated
- 17 February 2026
- Original description
Amyotrophic Lateral Sclerosis (ALS) progressively damages the nerve cells responsible for voluntary muscle movement. Over time, this leads to weakness in different muscles such as those used for movement or breathing. Breathing problems are one of the main causes of complications and reduced survival in people with ALS. This happens because the inspiratory muscles-those that help draw air into the lungs-gradually lose strength.Read full original descriptionShow less
Efficacy of Inspiratory Muscle Training in Patients With Amyotrophic Lateral Sclerosis: A Clinical Trial
Amyotrophic Lateral Sclerosis (ALS) progressively damages the nerve cells responsible for voluntary muscle movement. Over time, this leads to weakness in different muscles such as those used for movement or breathing. Breathing problems are one of the main causes of complications and reduced survival in people with ALS. This happens because the inspiratory muscles-those that help draw air into the lungs-gradually lose strength.
The study has the aim to explore the benefits of training inspiratory muscles in ALS patients in order to maintain the setrength of these muscles for as long as possible and look the impact on respiratory function.
Inclusion: Patients diagnosed with spinal ALS; men and women; diagnosis date less than two years ago, according to the "El Escorial" criteria (Appendix 2); PIM above the lower limit of normal; Preserved lung function (FVC ≥ 80%, FEV1 ≥ 80%, FEV1/FVC ≥ 80%) and normal values in supine position.
Exclusion: Any contraindication to the use of IMT. Severe psychiatric illness; Patients with signs of respiratory muscle weakness (MIP and MEP below the LLN and abnormal decubitus tests19-21); Nocturnal hypoventilation; Inability to perform the measurement tests; Inability to understand and perform the exercises.