Testing a head-worn ultrasound device to find abnormal blood shunts in people with HHT
Tests the SONAS ultrasound device for detecting shunts in adults with hereditary hemorrhagic telangiectasia.
Plain-language title generated from the registry record
Registry title: Non-Invasive Detection of Pulmonary Right-to-Left Shunts Using the SONAS Ultrasound Device
Key facts
- Where
- Nieuwegein, NetherlandsSee the site
Where in Netherlands
- St. Antonius HospitalNieuwegein, NetherlandsTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- St. Antonius Hospital
- Trial code
- NCT07414446
- Record updated
- 17 February 2026
- Original description
The goal of this clinical trial is to learn how well the SONAS ultrasound device can detect right-to-left shunts of adults with hereditary hemorrhagic telangiectasia (HHT) who are already scheduled for a contrast bubble echocardiogram (TTCE). The main questions it aims to answer are:Read full original descriptionShow less
Novel Approach For The Non-Invasive Detection of Pulmonary Right-to-Left Shunts
The goal of this clinical trial is to learn how well the SONAS ultrasound device can detect right-to-left shunts of adults with hereditary hemorrhagic telangiectasia (HHT) who are already scheduled for a contrast bubble echocardiogram (TTCE). The main questions it aims to answer are:
1. How accurately does SONAS detect right-to-left shunts compared to the standard TTCE test? 2. Can SONAS results help tell the difference between shunts in the heart and shunts in the lungs?
Participants will wear a headband with the SONAS device on the head while they undergo their routine TTCE bubble test. They will receive the usual contrast (agitated saline) through a vein, and both SONAS and TTCE signals will be recorded at the same time. There will be one examination in rest, and one during a breathing exercise (the Valsalva manoeuvre).
Inclusion: Age 18 years or older; Suspected or confirmed hereditary hemorrhagic telangiectasia (HHT); Incidentally: Patients who have experienced cryptogenic stroke.
Exclusion: Patients with known metal skull implants in the anatomical area of the temporal / parietal bones, or with anatomical formation of the head or ear tha may interfere with proper headset placement; Patients with known allergies or reactions to parabens, which are present in the gel pad material of the applied part; Pregnancy or breastfeeding; Known or suspected fracture(s) of the temporal / parietal skull bones, or with open skin injuries in the anatomical area of the temporal / parietal lobes.