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Parathyroidectomy After Kidney Transplantation

Key facts

Who runs it
Aarhus University Hospital
Where
Denmark1 site in 1 countryChoose a country to see its sites
Trial code
Status
Recruiting
People taking part
85 people, planned
Started
3 Mar 2026
Expected to end
31 Dec 2030
Type of study
Interventional, 2 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • Subtotal Parathyroidectomy
  • Conservative Management
Record updated
26 June 2026

Who can take part

Age
18 years and older
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 15 criteriaShow less

Who can take part

  • Age > 18 years and legally competent and able to understand spoken and written Danish
  • Kidney transplantation ≥6 months prior (no upper limit of time after transplantation)
  • Stable kidney graft function, defined as estimated GFR ≥ 30 ml/min/1.73m3
  • On minimum two separate biochemical measurements:; PTH > upper normal limit of assay and
  • serum ionized calcium ≥1.33 mmol/L or
  • serum total calcium ≥2.60 mmol/L or
  • serum phosphate ≤0.60 mmol/L despite sufficient dietary intake; with measurements obtained within
  • 3 months in patients 6-12 months post-transplant
  • 6 months in patients >12 months post-transplant; and not attributable to calcium supplementation or treatment with thiazide diuretics or lithium

Who cannot take part

  • Current anti-resorptive therapy (bisphosphonate, denosumab)
  • Current bone anabolic therapy (teriparatide, romosozumab)
  • Previous surgical parathyroidectomy
  • Not considered fit for surgery (including pregnancy)
  • Ionized calcium ≥1.50 mmol/L or albumin-corrected calcium ≥3.00 mmol/L despite discontinuation of calcium supplements
  • Inability to provide written, informed consent

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

This study aims to clarify whether surgical treatment of persistent hyperparathyroidism after kidney transplantation offers clinically meaningful benefits compared with a conservative treatment strategy.

Read full original descriptionShow less

Kidney transplant recipients (>6 mo after transplantation) with persistent hyperparathyroidism (elevated PTH and either hypercalcemia or hypophosphatemia) will be randomized in a 1:1 ratio to either subtotal parathyroidectomy or conservative management according to standard clinical practice. The study is conducted as an open-label, randomized controlled pilot trial with a 12-month follow-up period.

Outcomes include bone density, physical function, quality of life and symptom burden.

The 2 groups in the trial

  • Surgery groupTreatment being tested

    Participants assigned to this arm will undergo subtotal parathyroidectomy performed according to standard surgical practice. The procedure involves removal of the majority of parathyroid tissue with preservation of a small remnant. Intraoperative parathyroid hormone (PTH) measurements will be used to guide the extent of resection, in accordance with standard surgical principles. Surgery will be performed by experienced ear, nose and throat (ENT) surgeons. Participants will receive standard perioperative care and postoperative follow-up.

    Treatment: Subtotal Parathyroidectomy

  • Control groupExisting treatment, for comparison

    Participants assigned to this arm will receive conservative management according to standard clinical practice. This includes regular clinical follow-up and biochemical monitoring of calcium, phosphate, and parathyroid hormone levels. Medical treatment, such as calcium or vitamin D supplementation and/or calcimimetic therapy, may be initiated or adjusted at the discretion of the treating physician. No parathyroid surgery will be performed during the 12-month study period.

    Treatment: Conservative Management

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Subtotal Parathyroidectomy for the Treatment of Persistent Hyperparathyroidism After Kidney Transplantation
Record updated
26 June 2026