Focused ultrasound on the brain for movement disorders and other neurological conditions
Tests focused ultrasound to see how it affects brain activity in adults.
Plain-language title generated from the registry record
Registry title: LIFUS For Neurological Disorders
Key facts
- Where
- Toronto, CanadaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 18-85 who have a neurological or psychiatric disorder, such as epilepsy, a movement disorder or substance abuse disorder, and who are on medical or surgical treatment. It tests low-intensity focused ultrasound on the brain.
- Age
- 18 to 85 years
- Sex
- All sexes can join.
- Disease stage
- A diagnosed neurological disorder (such as epilepsy, brain tumour, movement disorders) or psychiatric disorder (such as substance abuse disorder).
- Earlier treatment
- People must be on medical or surgical treatment for a neurological disorder (such as DBS).
Main reasons for not taking part
- History of stroke
- Dementia as another condition
- Score below 22 on the Montreal Cognitive Assessment (MoCA)
- Implanted cardiac pacemaker or implantable cardioverter-defibrillator (ICD)
- Pregnancy
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 85 years old?
Source: NCT07417280, who can take part
Where in Canada
- Toronto Western Hospital, 399 Bathurst StToronto, CanadaContact: Alyssa SchleiferTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- University Health Network, Toronto
- Trial code
- NCT07417280
- Record updated
- 13 August 2026
- Original description
Low intensity focused ultrasound (LIFUS) has the potential to be used as a means of non-invasive neuro-modulation. To this day, the use of LIFUS is under investigation. Studies in healthy subjects have shown that application of LIFUS to the motor region of the brain can mildly decrease neuron excitability in healthy controls. The purpose of the present study is to evaluate the effects of LIFUS on brain tissue excitability in patients with movement disorders in order to elucidate the therapeutic potential of LIFUS.Read full original descriptionShow less
Clinical Effects of Low-Intensity Focused Ultrasound Neuromodulation in Patients With Neurological and Psychiatric Disorders
Low intensity focused ultrasound (LIFUS) has the potential to be used as a means of non-invasive neuro-modulation. To this day, the use of LIFUS is under investigation. Studies in healthy subjects have shown that application of LIFUS to the motor region of the brain can mildly decrease neuron excitability in healthy controls. The purpose of the present study is to evaluate the effects of LIFUS on brain tissue excitability in patients with movement disorders in order to elucidate the therapeutic potential of LIFUS.
Inclusion: 18-85 years of age; Patients diagnosed with neurological disorders, (such as epilepsy, brain tumour, movement disorders) or psychiatric disorders (such as substance abuse disorder); Patients undergoing medical or surgical treatment (such as DBS) for neurological disorders.
Exclusion: Receiving a psychotropic medication or taking recreational substances that in the opinion of the investigator will significantly affect safety of the protocol; History of stroke; Comorbid dementia; Has an implanted cardiac pacemaker or implantable cardioverter-defibrillator (ICD); Major depression/psychiatric disorder that in the opinion of the Investigator will affect patient's understanding of study procedures and willingness to abide by all procedures during the course of the study; Major systemic illness or infection; Scored below 22 on the Montreal Cognitive Assessment (MoCA); Presence of metal implanted in body that is contraindicated in TMS/MRI; Pregnancy.