NCT07417410Recruiting
Analysis of DR Progression to Identify Risks and Need for Treatment
Source: ClinicalTrials.gov · Last updated 2 Mar 2026
Brief summary (registry, in English)
The goal of this observational study is to understand whether vascular and structural changes in the eyes caused by diabetes can help predict which people are more likely to experience worsening diabetic retinopathy (a diabetes-related eye disease) and how these eye changes are related to cardiovascular complications. The study will include about 1,000 people with type 2 diabetes, aged 35 to 90 years, and will take place over twelve months. It may also include a retrospective component, where existing medical and imaging data collected from previous visits (within the last 1 to 5 years) will be analyzed. The main questions it aims to answer are: * Can eye vessel and tissue changes, observed through modern imaging techniques and clinical data, help better describe and predict which cases of diabetic retinopathy will become more severe? * Can these same eye changes help predict the presence and risk of cardiovascular problems-such as heart disease or stroke-in people living with type 2 diabetes?
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 1000 (estimated)
- First submitted
- 19 Nov 2025
- Start date
- 3 Nov 2025
- Primary completion date
- Nov 2026
- Lead sponsor
- Association for Innovation and Biomedical Research on Light and Image
- Diseases
- Diabetic eye disease
- NCT number
- NCT07417410
What you commit to
- Study type: Observational
- Planned participants: 1000
- From 3 Nov 2025 to the primary completion date, Nov 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous laser photocoagulation or intravitreal injections (consider if corticosteroids were administered).
- Any ocular surgery within the previous 3 months.
- Renal Replacement Therapy (Hemodialysis, Peritoneal Dialysis).
Other illness
- Severe systemic illness, subject to investigator's judgment.
Other
- Presence of clinically significant macular edema (CSME) with vision loss or requiring immediate treatment.
- Proliferative diabetic retinopathy.
Who the study is looking for
- Diagnosed with type 2 diabetes according to the 1985 WHO criteria.
- Age between 35 and 90 years.
- Retrospective visit or referenced patients. For the retrospective visit, a documented follow-up of 1-5 years is required, with at least one clinical visit. For the referenced patients, it is required that they have either diabetic retinopathy at the baseline visit, the presence of at least one cardiovascular risk factor at the baseline visit, or cardiovascular complications at the baseline visit.
- Signed informed consent.
Age in the registry: 35 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| AIBILI-Clinical Trial Centre Coordinator of this site? Confirm its status | Portugal | Portugal | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.