Adapted physical activity and muscle oxygen recovery in menopausal women with depression
Tests an adapted exercise program in postmenopausal women with major depression.
Plain-language title generated from the registry record
Registry title: Interest of Adaptated Physical Activity (APA) on the K Recovery Constant, Reflecting the Rate of Muscle Oxygenation Recovery in Menopausal Women Suffering From Depression
Key facts
- Where
- Besançon, FranceSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for menopausal women aged 40 or older who have a major depressive episode and have been on stable antidepressant treatment.
- Age
- 40 years or older
- Sex
- Women only (menopausal)
- Disease stage
- Major depressive episode according to DSM-V, with a score of 11 or more on the QIDS-C16 depression scale
- Earlier treatment
- Stable antidepressant treatment for at least 4 weeks
Main reasons for not taking part
- Medical reason not to do physical activity (heart or blood vessel disease, or past heart disease)
- Asthma or another unstable condition that limits physical effort
- Fat layer on the forearm thicker than 12 mm, which makes the muscle oxygen measurement unusable
Read by machine on 13 November 2026.
Where in France
- CHU de BesançonBesançon, FranceContact: Karine CHARRIERE, PhDNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Centre Hospitalier Universitaire de Besancon
- Trial code
- NCT07417709
- Record updated
- 18 February 2026
- Original description
APhyDeM is a randomized controlled study investigating the relationship between adapted physical activity and mitochondrial function in postmenopausal women with major depressive disorder.Read full original descriptionShow less
Interest of Adaptated Physical Activity (APA) on the K Recovery Constant, Reflecting the Rate of Muscle Oxygenation Recovery in Menopausal Women Suffering From Depression
APhyDeM is a randomized controlled study investigating the relationship between adapted physical activity and mitochondrial function in postmenopausal women with major depressive disorder.
Depression is associated with metabolic dysfunction, including alterations in mitochondrial activity and inflammatory processes. Physical activity has been shown to influence mitochondrial function, yet individuals with depression frequently experience reduced physical activity levels.
This study aims to evaluate whether an adapted physical activity program can improve mitochondrial function compared with a control intervention. Mitochondrial function will be indirectly assessed using near-infrared spectroscopy to measure post-exercise muscle oxygen recovery kinetics.
The study compares adapted physical activity with a non-physical therapeutic intervention in postmenopausal women receiving care in a psychiatric day hospital setting.
Inclusion: Menopaused women aged ≥ 40 years old,; Suffering from a major depressive episode according to international Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-V); Presenting a score ≥11 on the 16-item Quick Inventory of Depressive Symptomatology Clinician Rating (QIDS-C16) depression scale; With a stabilized teatment by antidepressors since at least 4 weeks.
Exclusion: Medical contraindication for physical activity (cardio-vascular pathology, and/or previous cardiac disease); Asthma or other unstabilized condition impairing the ability to perform physical exertion; Adipose tissue thickness measured on the forearm > 12 mm causing muscle oxygenation measurement by NIRS to be non contributive.