The Liver Cirrhosis Cognitive Decline Scale (LiCCoS)
Key facts
- Where
- Ambāla, IndiaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT07418008, who can take part
Where in India
- Maharishi Markandeshwar (Deemed to be University)Ambāla, IndiaContact: Rajat Rana, PhDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- University of Malaya
- Trial code
- NCT07418008
- Record updated
- 18 February 2026
- Original description
The goal of this observational study is to develop and test a new questionnaire called the Liver Cirrhosis Cognitive Decline Scale (LiCCoS) for adults with liver cirrhosis. This questionnaire is designed to help identify problems with thinking and daily mental functioning that are common in people with liver cirrhosis but are often missed during routine care.Read full original descriptionShow less
Development and Psychometric Validation of The Liver Cirrhosis Cognitive Decline Scale (LiCCoS)
The goal of this observational study is to develop and test a new questionnaire called the Liver Cirrhosis Cognitive Decline Scale (LiCCoS) for adults with liver cirrhosis. This questionnaire is designed to help identify problems with thinking and daily mental functioning that are common in people with liver cirrhosis but are often missed during routine care.
People with liver cirrhosis may experience problems such as forgetfulness, slowed thinking, trouble paying attention, or difficulty planning everyday tasks. These problems can affect daily life, safety, and treatment adherence. Existing cognitive tests often require special training or equipment and may not fully reflect how people experience these difficulties in daily life. This study aims to create a simple, patient-reported tool that captures these concerns in an easy and practical way.
The main questions this study aims to answer are:
1. Can the LiCCoS questionnaire reliably measure cognitive difficulties in adults with liver cirrhosis? 2. Does the questionnaire correctly reflect differences in cognitive function across levels of liver disease severity? 3. Do LiCCoS scores relate to results from commonly used cognitive screening tests?
Participants will be adults aged 18 to 75 years who have a confirmed diagnosis of liver cirrhosis and are attending outpatient clinics. Participation is voluntary.
Participants will:
Provide basic background information, such as age and medical history
Complete the LiCCoS questionnaire about their thinking and daily mental functioning
Complete standard cognitive screening tests commonly used in clinical care
This study does not involve any treatment or change in medical care. The information collected will be used only for research purposes. The results are expected to help develop a reliable and easy-to-use tool that can support early recognition of cognitive difficulties in people with liver cirrhosis and improve communication between participants and health care providers.
Inclusion: Age 18-75 years; Documented clinical diagnosis of liver cirrhosis based on imaging, histology, or validated clinical criteria; Able to read and understand the language of the cognitive tests; Willing and able to provide written informed consent.
Exclusion: Known case of Severe uncorrected visual or hearing impairment limiting ability to complete cognitive testing; Known case of Any neurological and psychological disorders, substance use disorder and sleep disorders; Known case of Severe systemic illness (e.g., end-stage renal disease, decompensated heart failure) that may independently impair cognition or limit participation; Age <18 or >75 years; Known case of Overt Hepatic Encephalopathy defined as Grade II or higher on the West Haven criteria [25]; Use of central nervous system depressants, anticholinergics, or psychotropics initiated or changed within the past 4 weeks.