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FDI and APL Muscle Activation During Thumb Exercises in CMC Osteoarthritis

Key facts

Who runs it
University of Malaga
Where
Spain1 site in 1 countryChoose a country to see its sites
Trial code
Status
Completed
People taking part
30 people enrolled
Started
28 Feb 2026
Ended
28 Aug 2026
Type of study
Observational
Record updated
8 October 2026

Who can take part

Age
18 years and older
Sex
Women and men
Healthy volunteers
Can take part

The registry criteria, word for word

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Who can take part

  • Over 18 years of age
  • Agreed to participate in the study, signing informed consent
  • Ability to read and understand the patient information sheets and exercises
  • Clinical diagnosis of thumb carpometacarpal osteoarthritis on the dominant hand grade 1-4 according to the Eaton-Littler Classification

Who cannot take part

  • Received treatment for hand or thumb pain in the same limb in the last 6 months
  • Previous surgery to the wrist or hand
  • Systemic conditions known to cause peripheral neuropathy
  • Cognitive impairment that inhibited understanding of the informed consent or exercise program
  • Presence of upper limb sensory disturbances
  • Upper limb entrapment neuropathy or cervical radiculopathy
  • Rheumatoid arthritis
  • Fracture or significant hand/thumb injury in the last 6 months

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

The aim of this study is to investigate whether there are differences in muscle activation of the First Dorsal Interosseous (FDI) and the Abductor Pollicis Longus (APL) between individuals with and without trapeziometacarpal osteoarthritis (TMC OA) of the thumb. The study also seeks to identify which exercises are most effective for activating these muscles, in order to inform rehabilitation strategies for patients.

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The FDI has been defined as a key stabilizer of the thumb TMC joint. However, the literature reports various protocols for FDI activation and limited information on APL behavior during these exercises. OA TMC of the thumb can cause pain, decreased thumb strength, impaired hand function, and difficulty performing activities of daily living (ADLs). Appropriate rehabilitation is essential to maintain muscle function, limit joint degeneration, and improve hand performance; however, the exercises that optimally activate the FDI and APL muscles are not yet established.

Participants will perform a series of standardized exercises and functional tasks designed to activate the FDI and APL muscles. Exercises include FDI strengthening with elastic bands in different hand positions (palmar and ulnar support), as well as exercises with the thumb in greater abduction. Functional tasks simulating everyday activities (e.g., turning a key, picking up a coin, writing, squeezing a tube of toothpaste, and holding a glass of water) will also be performed. Muscle activity will be recorded using surface electromyography (sEMG) during all tasks.

Adults aged 40 years and older, both men and women, with TMC osteoarthritis and healthy controls without osteoarthritis will be invited to participate.

Researchers will measure the activation patterns of the FDI and APL muscles during FDI activation exercises . The study aims to identify exercises that optimally activate these muscles, providing evidence to guide the rehabilitation of patients with thumb base osteoarthritis.

The group in the trial

  • OA GROUP

    Adults aged 18 years and older with a clinical diagnosis of thumb trapeziometacarpal (TMC) osteoarthritis. Participants will perform six standardized exercises designed to selectively activate the first dorsal interosseous (FDI) muscle, while surface electromyography (sEMG) of the FDI and abductor pollicis longus (APL) muscles is recorded. No pharmacological or physical intervention is administered beyond the exercises themselves; this is an observational measurement of muscle activation during standardized exercise performance.

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
First Dorsal Interosseous Exercises Reveal Altered Recruitment for the FDI and APL in Thumb Carpometacarpal Osteoarthritis. A Cross-Sectional EMG Study
Record updated
8 October 2026