FDI and APL Muscle Activation During Thumb Exercises in CMC Osteoarthritis
Key facts
- Who runs it
- University of Malaga
- Where
- Spain1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 30 people enrolled
- Started
- 28 Feb 2026
- Ended
- 28 Aug 2026
- Type of study
- Observational
- Record updated
- 8 October 2026
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
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Who can take part
- Over 18 years of age
- Agreed to participate in the study, signing informed consent
- Ability to read and understand the patient information sheets and exercises
- Clinical diagnosis of thumb carpometacarpal osteoarthritis on the dominant hand grade 1-4 according to the Eaton-Littler Classification
Who cannot take part
- Received treatment for hand or thumb pain in the same limb in the last 6 months
- Previous surgery to the wrist or hand
- Systemic conditions known to cause peripheral neuropathy
- Cognitive impairment that inhibited understanding of the informed consent or exercise program
- Presence of upper limb sensory disturbances
- Upper limb entrapment neuropathy or cervical radiculopathy
- Rheumatoid arthritis
- Fracture or significant hand/thumb injury in the last 6 months
This trial has no sites in United States.
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About the trial
What the trial wants to find out
The aim of this study is to investigate whether there are differences in muscle activation of the First Dorsal Interosseous (FDI) and the Abductor Pollicis Longus (APL) between individuals with and without trapeziometacarpal osteoarthritis (TMC OA) of the thumb. The study also seeks to identify which exercises are most effective for activating these muscles, in order to inform rehabilitation strategies for patients.
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The FDI has been defined as a key stabilizer of the thumb TMC joint. However, the literature reports various protocols for FDI activation and limited information on APL behavior during these exercises. OA TMC of the thumb can cause pain, decreased thumb strength, impaired hand function, and difficulty performing activities of daily living (ADLs). Appropriate rehabilitation is essential to maintain muscle function, limit joint degeneration, and improve hand performance; however, the exercises that optimally activate the FDI and APL muscles are not yet established.
Participants will perform a series of standardized exercises and functional tasks designed to activate the FDI and APL muscles. Exercises include FDI strengthening with elastic bands in different hand positions (palmar and ulnar support), as well as exercises with the thumb in greater abduction. Functional tasks simulating everyday activities (e.g., turning a key, picking up a coin, writing, squeezing a tube of toothpaste, and holding a glass of water) will also be performed. Muscle activity will be recorded using surface electromyography (sEMG) during all tasks.
Adults aged 40 years and older, both men and women, with TMC osteoarthritis and healthy controls without osteoarthritis will be invited to participate.
Researchers will measure the activation patterns of the FDI and APL muscles during FDI activation exercises . The study aims to identify exercises that optimally activate these muscles, providing evidence to guide the rehabilitation of patients with thumb base osteoarthritis.
The group in the trial
- OA GROUP
Adults aged 18 years and older with a clinical diagnosis of thumb trapeziometacarpal (TMC) osteoarthritis. Participants will perform six standardized exercises designed to selectively activate the first dorsal interosseous (FDI) muscle, while surface electromyography (sEMG) of the FDI and abductor pollicis longus (APL) muscles is recorded. No pharmacological or physical intervention is administered beyond the exercises themselves; this is an observational measurement of muscle activation during standardized exercise performance.
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- First Dorsal Interosseous Exercises Reveal Altered Recruitment for the FDI and APL in Thumb Carpometacarpal Osteoarthritis. A Cross-Sectional EMG Study
- Record updated
- 8 October 2026