AI software that reads chest X-rays to screen for osteoporosis
Compares AI reading of chest X-rays with DXA scans for osteoporosis in older adults.
Plain-language title generated from the registry record
Registry title: A Study Evaluating the Performance of Using AI Software and Chest X-rays to Screen for Osteoporosis as Compared to Standard DXA Scans in Patients 50 Years and Older
Key facts
- Where
- Rotterdam, NetherlandsSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
This study looks back at existing records of adults aged 50 and older who had both a chest X-ray and a DXA bone scan. It checks how well AI software spots osteoporosis risk on the X-ray. Nobody takes part directly.
- Age
- 50 years and older at the time of the chest X-ray
- Sex
- All sexes
- Earlier treatment
- People with an earlier osteoporosis diagnosis or recent anti-osteoporosis medicine, as set out in the exclusions, cannot be included.
- Biomarker or test result
- A valid DXA T-score is needed. The chest X-ray (PA view) and the DXA scan must be done within 6 months (182 days) of each other, on or after 01-Jan-2010.
Main reasons for not taking part
- Poor-quality or incomplete chest X-ray or DXA scan
- Earlier osteoporosis diagnosis (T-score ≤-2.5) or anti-osteoporosis medicine, as set out in the criteria
- Any other metabolic bone disease
- Major chest wall or spine deformity, metal implants or lung findings that hide the bones
- Has opted out of the use of their data for research
Read by machine on 12 November 2026.
Where in Netherlands
- Erasmus University Medical Center RotterdamRotterdam, NetherlandsContact: Jacob J Visser, Musculoskeletal Radiologist (principal investigator)Not yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Promedius Inc
- Trial code
- NCT07421713
- Record updated
- 23 October 2026
- Original description
The goal of this study is to assess the performance of an artificial intelligence software (Osteo Signal) in detecting osteoporosis risk in adults 50 years and older. The main question it aims to answer is: What is the accuracy of the software in detecting osteoporosis risk on chest x-ray images as compared to the standard technique of dual-energy x-ray absorptiometry (DXA)? There is no direct involvement of participants in this study as it will use data from individuals who have already had a chest x-ray and a DXA scan taken in the past.Read full original descriptionShow less
A Retrospective Multi-centre Paired Accuracy Study to Evaluate the Performance of Osteo Signal Against the Dual-energy X-ray Absorptiometry (DXA) for Opportunistic Osteoporosis Screening
The goal of this study is to assess the performance of an artificial intelligence software (Osteo Signal) in detecting osteoporosis risk in adults 50 years and older. The main question it aims to answer is: What is the accuracy of the software in detecting osteoporosis risk on chest x-ray images as compared to the standard technique of dual-energy x-ray absorptiometry (DXA)? There is no direct involvement of participants in this study as it will use data from individuals who have already had a chest x-ray and a DXA scan taken in the past.
Inclusion: Age ≥50 years at the time of chest X-ray; Availability of; Posteroanterior (PA) Chest X-ray and; DXA scan with a valid T-score measurement where both the DXA scan and Chest x-ray examinations were performed within 6 months (182 days) of each other and; Available X-ray and DXA scans performed on or after 01-Jan-2010; Complete metadata (sex and age) available on PACS or hospital records.
Exclusion: Previous diagnosis or treatment of Osteoporosis prior to the DXA scan used in the Study; diagnosis of osteoporosis (T-score ≤-2.5), or current/recent anti- osteoporotic medications, within 12 months prior to the DXA scan used in the study; Current or recent anti-osteoporotic medications for 3 months (91 days) continuously prior to the Chest x-ray used in the Study; Diagnosis of any metabolic bone disease prior to the DXA scan used in the study; Major Chest Wall or Spinal Deformities, including but not limited to:; Severe structural deformities: Thoracic scoliosis with Cobb angle >40°, severe kyphosis, or chest wall deformities (pectus excavatum/carinatum) affecting >30% of the thoracic cage; Surgical hardware: Previous thoracic/spinal surgery with metallic implants obscuring anatomical landmarks required for AI analysis; Pathological conditions: Extensive pulmonary consolidation, pleural effusion, lesions or masses obscuring >30% of thoracic skeletal structures; Diagnosis of metabolic bone disease other than Osteoporosis or Osteopenia, up to a maximum of 3 months (91 days) after the DXA scan; Non-diagnostic Quality or Incomplete Imaging of:; DXA scan inadequacy: Missing T-score from a technically inadequate scan; PA Chest X-ray technical inadequacy: Non-PA projection, significant motion artefacts, inadequate visualisation of thoracic structures, or missing DICOM metadata; Image format incompatibility: Non-DICOM format or corrupted image files that would prevent AI analysis; PA Chest X-ray > ±6 months from the date of the DXA scan; Subject has opted out of confidential data being used for research purposes.